Abstract
Cancer cell migration is a leading cause of tumor recurrence and treatment failure. Previously, we reported that marchantin C exhibited promising antitumor activity by inducing microtubule depolymerization and apoptosis. In the present study, we investigated the effect of marchantin C on inhibition of migration in T98G and U87 cells. The scratch-induced migration, Boyden chamber and cell invasion assays were applied to determine that the migrating capacity and invasiveness of these glioma cell lines were inhibited when exposed to marchantin C at a low concentration. There are no obvious signs of apoptosis with this dose. Western blot analyses confirmed that MMP-2, a key role in cancer cell migration, was reduced after incubation with marchantin C in both glioma cell lines. In addition, signaling pathway investigations demonstrated that ERK/MAPK might be involved in MMP-2 downregulation, rather than the AKT/PI3K or JAK/STAT3 pathways. Moreover, marchantin C potently suppressed angiogenesis activity in vivo by CAM assay. This is the first study to demonstrate that marchantin C can inhibit glioma cell migration and invasiveness.
Citations
Aug 31, 2013·PloS One·Guocai GuoYongli Bo
Jun 28, 2011·European Journal of Pharmacology·Cui-cui SunXian-jun Qu
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Yafeng LvXingang Li
Mar 5, 2015·Journal of Cellular Biochemistry·Shaofeng YanGang Li
Jan 21, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xia XueXian-Jun Qu
Aug 27, 2013·Cancer Biology & Therapy·Paul Dent
Apr 1, 2014·Cancer Letters·Leilei NiuHongxiang Lou
Sep 15, 2010·Chemico-biological Interactions·Wea-Lung LinTsui-Hwa Tseng
Oct 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shaofeng YanGang Li
May 18, 2017·Organic Letters·Émilie MorinShawn K Collins
Nov 18, 2011·Natural Product Reports·David C Harrowven, Sarah L Kostiuk
Mar 7, 2017·PloS One·Xin WangQuanxi Wang
Jul 25, 2019·BMC Complementary and Alternative Medicine·Sumira MukhiaDevendra Singh
Mar 16, 2021·Frontiers in Oncology·Zui ChenTing Zhang
Jun 3, 2021·Plants·Ivana IvkovićDanka Bukvički
Oct 12, 2017·Journal of Natural Products·Yoshinori Asakawa, Agnieszka Ludwiczuk