Marchantin C: a potential anti-invasion agent in glioma cells

Cancer Biology & Therapy
Jie ShenHong-xiang Lou

Abstract

Cancer cell migration is a leading cause of tumor recurrence and treatment failure. Previously, we reported that marchantin C exhibited promising antitumor activity by inducing microtubule depolymerization and apoptosis. In the present study, we investigated the effect of marchantin C on inhibition of migration in T98G and U87 cells. The scratch-induced migration, Boyden chamber and cell invasion assays were applied to determine that the migrating capacity and invasiveness of these glioma cell lines were inhibited when exposed to marchantin C at a low concentration. There are no obvious signs of apoptosis with this dose. Western blot analyses confirmed that MMP-2, a key role in cancer cell migration, was reduced after incubation with marchantin C in both glioma cell lines. In addition, signaling pathway investigations demonstrated that ERK/MAPK might be involved in MMP-2 downregulation, rather than the AKT/PI3K or JAK/STAT3 pathways. Moreover, marchantin C potently suppressed angiogenesis activity in vivo by CAM assay. This is the first study to demonstrate that marchantin C can inhibit glioma cell migration and invasiveness.

Citations

Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Yafeng LvXingang Li
Mar 5, 2015·Journal of Cellular Biochemistry·Shaofeng YanGang Li
Jan 21, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xia XueXian-Jun Qu
Aug 27, 2013·Cancer Biology & Therapy·Paul Dent
Sep 15, 2010·Chemico-biological Interactions·Wea-Lung LinTsui-Hwa Tseng
Oct 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shaofeng YanGang Li
Nov 18, 2011·Natural Product Reports·David C Harrowven, Sarah L Kostiuk
Oct 12, 2017·Journal of Natural Products·Yoshinori Asakawa, Agnieszka Ludwiczuk

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