Marchiafava-Bignami disease: Two cases with magnetic resonance imaging and positron emission tomography scan findings

Neurology India
A NaliniKumar G Kallur

Abstract

We report two patients with Marchiafava-Bignami disease (MBD). A 38-year-old male with chronic alcohol abuse developed acute onset cerebellar ataxia and altered sensorium. He was diagnosed to have acute form (Type II) of MBD. Magnetic resonance imaging (MRI) showed extensive lesions involving the corpus callosum in its entire extent and also bilateral corona radiata and centrum semiovale. Corpus callosum had heterogeneous signal changes with ring enhancement. Positron emission tomography scan demonstrated reduced cerebral glucose metabolism diffusely over both the cerebral hemispheres. The second patient was 55-year-old male with chronic alcohol intake developed acute onset vomiting followed by behavioral abnormalities and altered sensorium. MRI showed diffuse lesion involving entire corpus callosum with suggestion of necrosis. Both the patients subsequently recovered, the first patient is back to his previous occupation and the second patient could be rehabilitated with some lighter work in his previous work place. Functional brain imaging may help to understand the pathogenesis of acute MBD and possibly the behavioral manifestations.

Citations

Aug 28, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Matti HillbomMaurizio A Leone
Feb 18, 2015·Neuroradiology·Tanja SchneiderDavid Mark Yousem
Oct 20, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yaoyao ShenHongbing Nie

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Related Papers

Neurología : publicación oficial de la Sociedad Española de Neurología
C VázquezP Cardinal
European Archives of Psychiatry and Clinical Neuroscience
T HumbertP Chabrand
Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
Levent AggunluSergin Akpek
© 2022 Meta ULC. All rights reserved