Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients

Laboratory Investigation; a Journal of Technical Methods and Pathology
Jiaqi GuSheng-Wei Jin

Abstract

Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in the pathogenesis of sepsis. Maresins have protective and resolving effects in experimental models of infection. In the present study, we investigated the effects of maresin 1 (MaR1) on mitochondrial function in cecal ligation and puncture (CLP)-induced sepsis and sepsis patients to identify mechanisms underlying maresin 1-mediated stimulation of ROS in mitochondria. We found that treatment with MaR1 significantly inhibited production of cytokines, decreased bacterial load in the peritoneal lavage fluid, reduced the number of neutrophils, decreased lactic acid level and upregulated cyclic AMP (cAMP) concentration, with the outcome of decreased lung injury in CLP-induced sepsis in mice. The effects of MaR1 on downregulation nitric oxide (NOX) activity, improvement CAT and SOD activity to inhibit ROS production in mitochondria was dependent on lipoxin receptor (ALX) and cAMP. Survival rates were significantly increased after the treatment of mice with MaR1. In BMDM stimulated with LPS, MaR1 inhibited the ROS production, downregulated enzyme activity, reduced...Continue Reading

References

Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·E D CrouserP M Dorinsky
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·E D CrouserJ A Bauer
Jan 3, 2001·Free Radical Biology & Medicine·L A CallahanG S Supinski
Mar 13, 2002·Critical Care Medicine·Elliott D CrouserDouglas R Pfeiffer
Dec 20, 2002·Nature·Carl Nathan
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Sep 14, 2006·Pharmacological Reviews·Nan ChiangCharles Brink
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle G SouzaMauro M Teixeira
Dec 24, 2008·The Journal of Experimental Medicine·Charles N SerhanMatthew Spite
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Nov 10, 2009·The Journal of Biological Chemistry·Cyrille ChevtzoffAnne Devin
Jan 27, 2010·Infection and Immunity·Jared T MuenzerRichard S Hotchkiss
Sep 4, 2010·The American Journal of Pathology·Charles N Serhan
Aug 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hicham BouabeJürgen Heesemann
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanNicos A Petasis
Mar 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jesmond DalliCharles N Serhan
Sep 28, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F ChenX M Deng
Mar 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qian WangSheng-Wei Jin
Jun 15, 2016·Free Radical Biology & Medicine·Plamena R Angelova, Andrey Y Abramov
Sep 21, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esther TitosJoan Clària
Nov 2, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Romain A ColasCharles N Serhan
Nov 5, 2016·Methods in Molecular Biology·Rabii Ameziane-El-Hassani, Corinne Dupuy
Feb 22, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun-Li ZhangSheng-Wei Jin
May 2, 2017·Biological & Pharmaceutical Bulletin·Takeshi MatsutaniEiji Uchida
Aug 15, 2017·Journal of Diabetes Investigation·Hiroshi TanakaMasaya Hosokawa

❮ Previous
Next ❯

Citations

Jan 7, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Michele G Padovan, Lucy V Norling
Jul 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sisi ZhengShengwei Jin
Jul 19, 2019·Oxidative Medicine and Cellular Longevity·Alessandro LeutiValerio Chiurchiù
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Clara Dos Reis NunesDaniela Barros de Oliveira
Jul 10, 2019·Current Pharmaceutical Design·Ying TanMaolong Dong
Dec 17, 2020·Frontiers in Immunology·Luca CioccariMojgan Masoodi
Dec 4, 2020·International Immunopharmacology·Rong ZhuangZhongqiu Lu
Mar 7, 2021·International Immunopharmacology·Lin-Chao LiSheng-Wei Jin
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luísa Teixeira-SantosDora Pinho
Aug 6, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Joan ClàriaCristina López-Vicario
Dec 11, 2021·Frontiers in Molecular Biosciences·Ingrid W ZhangJoan Clària

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
protein assay
PCR
lavage
flow cytometry
transmission electron microscopy
Assay
electron microscopy

Software Mentioned

Spot
Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved