Maresin1 Alleviates Metabolic Dysfunction in Septic Mice: A 1 H NMR-Based Metabolomics Analysis

Mediators of Inflammation
Yu HaoSheng-Wei Jin

Abstract

Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and puncture- (CLP-) induced septic mice. We found that MaR1 significantly increased the overall survival rate and attenuated lung and liver injuries in septic mice. In addition, MaR1 markedly reduced the levels of proinflammatory cytokines (TNF-α and IL-6) and alleviated mitochondrial damage. Based on a 1H NMR-based metabolomics analysis, CLP-induced septic mice had increased levels of acetate, pyruvate, and lactate in serum and decreased levels of alanine, aspartate, glutamate, and fumarate in lungs. However, these metabolic disorders, mainly involving energy and amino acid metabolism, can be recovered by MaR1 treatment. Therefore, our results suggest that the protective effects of MaR1 on sepsis could be related to the recovery of metabolic dysfunction and the alleviation of inflammation and mitochondrial damage.

References

Aug 3, 2004·Critical Care Medicine·H Bryant NguyenMichael C Tomlanovich
Apr 28, 2005·Annals of Emergency Medicine·Nathan I ShapiroJ Woodrow Weiss
Jun 17, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Martijn PoezeNicolaas E P Deutz
Dec 24, 2008·The Journal of Experimental Medicine·Charles N SerhanMatthew Spite
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Dec 17, 2009·Journal of Magnetic Resonance·F SavoraniS B Engelsen
Oct 5, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen A StringerTheodore J Standiford
Oct 7, 2011·Intensive Care Medicine·José L Izquierdo-GarcíaJosé A Lorente
Jul 28, 2012·The British Journal of Dermatology·S-H WuL Dong
Mar 22, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qian WangSheng-Wei Jin
Dec 17, 2014·Amino Acids·Hua ZhangYoshinori Mine
Apr 22, 2015·Nucleic Acids Research·Jianguo XiaDavid S Wishart
Jan 1, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Suruchi SinghRaja Roy
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Ruidong LiKaixiong Tao
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Mar 12, 2016·Nature Reviews. Drug Discovery·David S Wishart
Mar 15, 2016·Frontiers in Immunology·Kathleen A StringerPaige Lacy
Aug 26, 2016·Science Translational Medicine·Valerio ChiurchiùCharles N Serhan
Oct 14, 2016·Redox Report : Communications in Free Radical Research·Víctor MolinaCristian Carvajal
Nov 2, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Romain A ColasCharles N Serhan
Dec 31, 2016·Burns : Journal of the International Society for Burn Injuries·Carlos André Prauchner
Jan 4, 2017·Mediators of Inflammation·Ruidong LiKaixiong Tao
Jan 25, 2017·Nature Reviews. Disease Primers·Richard S HotchkissJean-Louis Vincent
Feb 22, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun-Li ZhangSheng-Wei Jin
Oct 21, 2017·Cell Death and Differentiation·Andreas KörnerValbona Mirakaj
Feb 23, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jiaqi GuSheng-Wei Jin
Apr 28, 2018·Experimental & Molecular Medicine·Xiao-Jun ZhuoSheng-Wei Jin

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Citations

Jan 7, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Michele G Padovan, Lucy V Norling
Nov 27, 2019·International Journal of Molecular Sciences·Sung-Min HwangChul-Kyu Park
May 8, 2020·Mediators of Inflammation·Tian MiaoHua Qu
Dec 17, 2020·Frontiers in Immunology·Luca CioccariMojgan Masoodi
Nov 20, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Victor FattoriWaldiceu A Verri
Nov 29, 2020·Immunology Letters·Victor FattoriWaldiceu A Verri

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Methods Mentioned

BETA
ELISA
electron
transmission electron microscopy
NMR
PCA

Software Mentioned

SIMCA
SPSS
TopSpin
MetaboAnalyst
MATLAB

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