Abstract
There is lack of consensus regarding re-excision in breast-conserving therapy (BCT) and close margins. We hypothesize that margin width does not predict residual disease. The cancer registry was queried from 2003 to 2008 for patients with BCT who underwent re-excision for <2-mm margins. Factors associated with additional disease were evaluated. One thousand eight hundred forty-three patients underwent BCT. Our re-excision rate was 42%. Clinicopathologic factors from 228 patients were analyzed. One hundred five patients (46%) had additional disease; of those, 58% had BCT and 42% mastectomy. One hundred twenty-three (54%) had no additional disease; of those 82% had BCT and 18% mastectomy. Of the 66 patients who underwent mastectomy, 44 (67%) had residual disease; of the 161 who had BCT, 61 (38%) had residual disease (P < 0.01). On univariate analysis, margin width did not correlate with residual disease. Multifocality, non-invasive histology, increasing number of close margins, and higher grade predicted additional disease (P < 0.05). On multivariate analysis, only number of close margins remained significant. Margin width does not predict additional disease. This challenges the practice of using this to select re-excision candid...Continue Reading
References
Nov 30, 1995·The New England Journal of Medicine·B FisherW M Cronin
Aug 15, 2000·Breast Cancer Research and Treatment·I de MascarelJ M Coindre
Nov 16, 2002·American Journal of Surgery·S Eva Singletary
Oct 14, 2003·American Journal of Surgery·Melvin J Silverstein
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa A Newman, Henry M Kuerer
Jun 14, 2006·Cancer·Gordon F SchwartzUNKNOWN Consensus Conference Committee
Aug 10, 2007·Breast Cancer Research and Treatment·Salomone Di SaverioMario Taffurelli
May 10, 2008·Acta Oncologica·Anne-Vibeke LaenkholmFritz Rank
Dec 10, 2008·Journal of Surgical Oncology·Michael S SabelLisa A Newman
Oct 23, 2009·Annals of Surgical Oncology·Michelle AzuMonica Morrow
Feb 18, 2010·Lancet·Lindsay TurnbullJulia Brown
Sep 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nehmat HoussamiLawrence J Solin
Nov 4, 2010·Annals of Surgical Oncology·Anne KobbermannRoshni Rao
Feb 3, 2012·JAMA : the Journal of the American Medical Association·Laurence E McCahillAdedayo A Onitilo
Mar 24, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S O GurdalV Ozmen
May 24, 2012·The Breast Journal·Can Atalay, Cigdem Irkkan
Sep 27, 2012·Annals of Surgical Oncology·Melissa S CampBarbara L Smith
Aug 27, 2013·Annals of Surgical Oncology·Theresa SchwartzJeffrey Landercasper
Citations
Jul 17, 2015·Annals of Surgical Oncology·Anne BodilsenPeer Christiansen
Jan 28, 2014·Journal of Surgical Oncology·Julie O'Brien, Monica Morrow
Jul 15, 2016·Annals of Surgical Oncology·Laura H RosenbergerMary L Gemignani
Nov 3, 2016·Annals of Surgical Oncology·Simon FitzgeraldElisa R Port
Jul 28, 2017·Journal of Surgical Oncology·Caitlin R PattenRichard L White
May 12, 2018·Annals of Surgical Oncology·Lisa J Findlay-ShirrasMaged Nashed
Jan 25, 2019·Scientific Reports·Cristina BausAlbert Costa
Jul 11, 2018·Annals of Surgical Oncology·Kari M RosenkranzJudy C Boughey
Jun 17, 2021·Breast Cancer Research and Treatment·Julie B SiegelAndrea M Abbott