PMID: 9160488Apr 30, 1997Paper

Marginal analysis of recurrent events and a terminating event

Statistics in Medicine
R J Cook, J F Lawless

Abstract

Chronic medical conditions are often manifested by the incidence of recurrent adverse clinical events. In clinical trials designed to investigate therapeutic interventions for such conditions it is natural to make treatment comparisons on the basis of event occurrence. However, when there is a more serious, possibly related, event that terminates the occurrence of the recurrent events, the problem of dependent censoring arises. Here, we consider robust modelling strategies for expressing covariate effects on the recurrent event process that address the possible dependence between the recurrent and terminal events. The various methods differ in the way the dependence is addressed, and hence in the interpretation of covariate effects. The methods are applied to a data set from a kidney transplant study and simulated data chosen for illustrative purposes.

Citations

Jul 1, 2014·Statistics in Biosciences·Dandan LiuDouglas E Schaubel
Apr 2, 2010·BMC Medical Research Methodology·Jisheng CuiAndrew Tonkin
Sep 18, 2008·Biostatistics·M FioccoJ C Van Houwelingen
Jan 28, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·David W EvansChristian Verger
Jul 6, 2000·Biometrics·D Ghosh, D Y Lin
Dec 18, 2001·Statistics in Medicine·J Sun
Mar 5, 2013·The American Journal of Cardiology·George A Diamond, Sanjay Kaul
Aug 13, 2015·Statistics in Medicine·Chyong-Mei ChenYa-Wen Chuang
Jul 29, 2015·Statistics in Medicine·Laura M Yee, Kwun Chuen Gary Chan
Sep 2, 2004·Biometrics·Lei LiuXuelin Huang
Jul 22, 2004·Transfusion·R J CookUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Working Party of the International Society for Blood Transfusion
Nov 24, 2004·Statistics in Medicine·Bingshu E ChenMin Zhan
Mar 26, 2003·Statistics in Medicine·D Y Lin
May 22, 2003·Transfusion·Nancy M HeddleUNKNOWN Biomedical Excellence for Safer Transfusion Working Party of the International Society for Blood Transfusion
Jul 6, 2007·Statistics in Medicine·Yang-Jin Kim, Myoungshic Jhun
Mar 10, 2006·Statistics in Medicine·Masako NishikawaMakiko Ogawa
Apr 24, 2007·Biometrics·Yining YeDouglas E Schaubel
Nov 3, 2010·Biometrics·Jin-Jian HsiehWeijing Wang
Oct 1, 2011·Biometrics·Dandan LiuJohn D Kalbfleisch
Dec 21, 2010·Statistics in Medicine·Paola ReboraMaria Grazia Valsecchi
Jul 25, 2012·Statistics in Medicine·Xuelin Huang, Jing Ning
Mar 19, 2014·Statistics in Medicine·Aurélien BelotUNKNOWN CENSUR working survival group
Feb 13, 2014·Pharmaceutical Statistics·Qi GongLiang Fang
Dec 20, 2014·Biometrical Journal. Biometrische Zeitschrift·Chyong-Mei ChenPao-Sheng Shen
Dec 9, 2004·The Breast : Official Journal of the European Society of Mastology·Robert E Coleman
Dec 31, 2002·Accident; Analysis and Prevention·Mau-Roung LinPenelope M Keyl
Aug 22, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·John A FordGraham Mowatt
Jan 28, 2014·Communications in Statistics: Theory and Methods·Hui ZhaoJianguo Sun
Jun 14, 2016·Pharmaceutical Statistics·Johannes HengelbrockFriedhelm Leverkus
Jul 8, 2016·Statistics in Medicine·Sijin WenPeter Pisters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.