Marginal ancestral contributions to atrial fibrillation in the Standardbred racehorse: Comparison of cases and controls

PloS One
Megan KrausFlávio S Schenkel

Abstract

Admissions of Standardbred racehorses (Std) to the Ontario Veterinary College Teaching Hospital (OVCTH) for treatment of atrial fibrillation (AF) began to increase in the early 1990s. The arrhythmia has been shown to have a modest heritability (h2 ≃ 0.15), with some stallions appearing as sires or sires of mares used in breeding (broodmares) of affected horses more frequently than others. The objective of this study was to determine the marginal genetic contributions of ancestors to cohorts of Std affected with AF and their contemporary control groups, and whether these ancestors contribute significantly more to the affected cohorts than to controls. All Std admitted to OVCTH for treatment of AF that were born between 1993 and 2007 comprised the affected case group (n = 168). Five randomly selected racing contemporaries for each Std admitted, assumed to not suffer from the arrhythmia, comprised the control group (n = 840). Three-year overlapping cohorts were created for case and control horses, determined according to year of birth, for a total of 26 cohorts. Marginal genetic contributions of ancestors to each cohort were determined and differences analyzed for statistical significance using a two-tailed paired t-test, with P ≤...Continue Reading

References

Apr 1, 1977·Equine Veterinary Journal·R J Rose, P E Davis
May 1, 1990·Australian Veterinary Journal·G A StewartC D McKellar
Mar 1, 1995·Journal of Veterinary Internal Medicine·V B ReefP A Spencer
Feb 28, 2003·Genetics, Selection, Evolution : GSE·Juan Pablo GutiérrezJesús Piedrafita
Sep 30, 2005·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M SargolzaeiJ-J Colleau
Oct 17, 2006·Journal of Animal Science·S Mc ParlandD P Berry
Dec 13, 2007·Journal of Animal Science·R A MartínezJ Cañón
Nov 1, 2005·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·M Kimberly J McGurrinDaniel G Kenney
Jun 30, 2010·Journal of Veterinary Internal Medicine·P W Physick-Sheard, M K J McGurrin
Aug 5, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Peter Physick-SheardFlavio Schenkel
Apr 10, 2017·Equine Veterinary Journal·M KrausF S Schenkel

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Citations

Oct 6, 2020·Equine Veterinary Journal·Peter W Physick-Sheard, Joann Slack
Feb 20, 2021·Journal of Veterinary Internal Medicine·Laura C NathSamantha Franklin
Jul 5, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·C PedlerS Franklin
Sep 27, 2021·Equine Veterinary Journal·Antoine PremontKamalan Jeevaratnam

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Methods Mentioned

BETA
chip
genotyping

Software Mentioned

CFC
PedigreeViewer
Pedig

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