Abstract
Admissions of Standardbred racehorses (Std) to the Ontario Veterinary College Teaching Hospital (OVCTH) for treatment of atrial fibrillation (AF) began to increase in the early 1990s. The arrhythmia has been shown to have a modest heritability (h2 ≃ 0.15), with some stallions appearing as sires or sires of mares used in breeding (broodmares) of affected horses more frequently than others. The objective of this study was to determine the marginal genetic contributions of ancestors to cohorts of Std affected with AF and their contemporary control groups, and whether these ancestors contribute significantly more to the affected cohorts than to controls. All Std admitted to OVCTH for treatment of AF that were born between 1993 and 2007 comprised the affected case group (n = 168). Five randomly selected racing contemporaries for each Std admitted, assumed to not suffer from the arrhythmia, comprised the control group (n = 840). Three-year overlapping cohorts were created for case and control horses, determined according to year of birth, for a total of 26 cohorts. Marginal genetic contributions of ancestors to each cohort were determined and differences analyzed for statistical significance using a two-tailed paired t-test, with P ≤...Continue Reading
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Citations
Oct 6, 2020·Equine Veterinary Journal·Peter W Physick-Sheard, Joann Slack
Feb 20, 2021·Journal of Veterinary Internal Medicine·Laura C NathSamantha Franklin
Jul 5, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·C PedlerS Franklin
Sep 27, 2021·Equine Veterinary Journal·Antoine PremontKamalan Jeevaratnam