Marginal grafts increase early mortality in liver transplantation

São Paulo Medical Journal = Revista Paulista De Medicina
Telesforo BacchellaMarcel Cerqueira César Machado

Abstract

Expanded donor criteria (marginal) grafts are an important solution for organ shortage. Nevertheless, they raise an ethical dilemma because they may increase the risk of transplant failure. This study compares the outcomes from marginal and non-marginal graft transplantation in 103 cases of liver transplantation due to chronic hepatic failure. One hundred and three consecutive liver transplantations to treat chronic liver disease performed in the Liver Transplantation Service of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo between January 2001 and March 2006 were retrospectively analyzed. We estimated graft quality according to a validated scoring system. We assessed the pre-transplantation liver disease category using the Model for End-Stage Liver Disease (MELD), as low MELD (< 20) or high MELD (>or= 20). The parameters for marginal and non-marginal graft comparison were the one-week, one-month and one-year recipient survival rates, serum liver enzyme peak, post-transplantation hospital stay and incidence of surgical complications and retransplantation. The significance level was 0.05. There were no differences between the groups regarding post-transplantation hospital stay, serum liver enzyme le...Continue Reading

References

Nov 26, 1994·Lancet·D F MirzaP McMaster
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·L De CarlisD Forti
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·S AgnesM Castagneto
Nov 20, 1997·Transplantation Proceedings·T KaratzasA G Tzakis
Sep 10, 1999·Transplantation·H V Melendez, N D Heaton
Dec 9, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·J BriceñoC Pera
May 16, 2002·Transplantation Proceedings·A S R AmaralJ O Medina-Pestana
May 16, 2002·Transplantation Proceedings·P S DuarteM Abbud-Filho
May 29, 2003·Critical Care Medicine·Michael A WilliamsUNKNOWN Council on Scientific Affairs, American Medical Association
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ronald W Busuttil, Koichi Tanaka
Jan 3, 2006·Transplantation Proceedings·M GastacaJ Ortiz de Urbina
Oct 4, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Flávio Henrique Ferreira GalvãoMarcel Cerqueira César Machado

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Citations

Sep 4, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Rajesh GodaraKapileshwer Vijay
Oct 1, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cheuk-Kwan SunPo-Han Chen
Jan 10, 2012·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Nhut Quang TranVijayaragavan Muralidharan
Sep 17, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zifa WangLibin Yang
Aug 27, 2015·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Riccardo MemeoDaniel Azoulay
May 31, 2011·Transplantation Proceedings·P S Vieira de MeloC M Lacerda
Dec 8, 2009·Revista latino-americana de enfermagem·Edvaldo Leal de MoraesAparecida de Jesus Guarino
Aug 21, 2016·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Somak DasAnand Ramamurthy
May 21, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Meysam MojtabaeeFarahnaz Sadegh-Beigee
Nov 16, 2013·Current Opinion in Organ Transplantation·Nataša ObermajerMarc H Dahlke
Jun 30, 2019·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Oleg SlivcaTimothy L Pruett
Feb 20, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Ioannis A ZiogasMartin I Montenovo
May 13, 2021·Revista do Colégio Brasileiro de Cirurgiões·Antonio Carlos Lugon Ferreira-JrThales Ribeiro Dos Santos Vecci
Jun 9, 2021·BMC Gastroenterology·Estela Regina Ramos FigueiraLuiz Augusto Carneiro D'Albuquerque

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