PMID: 11916761Mar 28, 2002Paper

Marginal iron deficiency without anemia impairs aerobic adaptation among previously untrained women

The American Journal of Clinical Nutrition
Thomas BrownlieJere D Haas

Abstract

Iron deficiency without anemia has been shown to reduce both muscle-tissue oxidative capacity and endurance in animals. However, the consequences of iron deficiency in humans remain unclear. We investigated the effects of iron supplementation on adaptation to aerobic training among marginally iron-depleted women. We hypothesized that iron supplementation for 6 wk would significantly improve iron status and maximal oxygen uptake (VO(2)max) after 4 wk of concurrent aerobic training. Forty-one untrained, iron-depleted, nonanemic women were randomly assigned to receive either 50 mg FeSO(4) or a placebo twice daily for 6 wk in a double-blind trial. All subjects trained on cycle ergometers 5 d/wk for 4 wk, beginning on week 3 of the study. Six weeks of iron supplementation significantly improved serum ferritin and serum transferrin receptor (sTfR) concentrations and transferrin saturation without affecting hemoglobin concentrations or hematocrit. Average VO(2)max and maximal respiratory exchange ratio improved in both the placebo and iron groups after training; however, the iron group experienced significantly greater improvements in VO(2)max. Both iron-status and fitness outcomes were analyzed after stratifying by baseline sTfR conc...Continue Reading

References

Aug 1, 1976·The Journal of Clinical Investigation·C A FinchB Mackler
Jul 1, 1988·Journal of Applied Physiology·W T WillisG A Brooks
Oct 1, 1986·American Journal of Hematology·C A FlowersJ D Cook
Nov 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·J P PersijnA Riethorst
May 1, 1969·Journal of Applied Physiology·R Akers, E R Buskirk
Jan 1, 1993·Medicine and Science in Sports and Exercise·B W TobinW L Kenney
Mar 26, 1997·JAMA : the Journal of the American Medical Association·A C LookerC L Johnson
Aug 1, 1997·The American Journal of Clinical Nutrition·Y I Zhu, J D Haas
Mar 10, 2000·Journal of Applied Physiology·P S HintonJ D Haas

❮ Previous
Next ❯

Citations

Aug 26, 2003·The American Journal of Clinical Nutrition·Janet R Hunt
May 11, 2005·The American Journal of Clinical Nutrition·Sharon R Akabas, Karen R Dolins
Oct 14, 2008·Medicine and Science in Sports and Exercise·Drorit MerkelEran Israeli
Jan 31, 2009·Nutrition Reviews·James P McClung, J Philip Karl
Aug 28, 2010·Biological Trace Element Research·Jesús VillanuevaJesús F Escanero
May 20, 2011·European Journal of Applied Physiology·Karsten KoehlerWilhelm Schänzer
Nov 15, 2011·Journal of Strength and Conditioning Research·Ran YanovichDaniel S Moran
May 26, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Scott E CrouterJere D Haas
Nov 8, 2013·Medicine and Science in Sports and Exercise·Diane M DellaValle, Jere D Haas
Aug 11, 2015·European Journal of Haematology·Jeremy J Pratt, Khalid S Khan
Sep 1, 2016·Wiener medizinische Wochenschrift·Bettina Wurzinger, Peter König
Jan 20, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Laura G Goetz, Claudia Valeggia
Jun 15, 2017·American Journal of Hematology·Maria Domenica CappelliniUNKNOWN IRON CORE Group
Jul 25, 2017·Journal of Strength and Conditioning Research·Elaine C LeeDouglas J Casa
Dec 14, 2018·Nutrients·Carla J Gargallo-PuyueloFernando Gomollon
Nov 28, 2018·Current Medical Research and Opinion·Maurizio Serati, Marco Torella
May 15, 2012·EFSA Journal·UNKNOWN EFSA Panel on Animal Health and Welfare (AHAW)
Oct 14, 2008·Medicine and Science in Sports and Exercise·Eran IsraeliDaniel S Moran
Feb 27, 2008·Food and Nutrition Bulletin·Sean LynchRahul Rawat
May 24, 2011·International Journal of Nephrology·Donald S SilverbergDoron Schwartz
Dec 15, 2012·European Journal of Applied Physiology·Yoram EpsteinYuval Heled
May 31, 2013·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Imad T Jarjour, Laila K Jarjour
Mar 1, 2014·Journal of the Science of Food and Agriculture·Saira SultanHafiz Ansar Rasul Suleria
Oct 27, 2012·European Heart Journal·Ewa A JankowskaPiotr Ponikowski
Apr 18, 2014·Transfusion·Hannah E SalvinJoanna Speedy
Jul 8, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anael Barberan-GarciaMauricio Orozco-Levi
Aug 8, 2017·Transfusion·José A L Calbet, Marcos Martin-Rincon
Feb 15, 2018·Nutrients·Raúl DomínguezAlberto Pérez-López
Jun 8, 2018·The Journal of Nutrition·Sean LynchDaniel J Raiten
Mar 5, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·P S RakeshK V Beena
Sep 21, 2004·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·George C PitsisRuth Fazakerley
Feb 1, 2007·Anesthesiology·Hans JutziAlain Borgeat
Jan 29, 2009·The British Journal of Nutrition·James P McClungHarris R Lieberman
Mar 3, 2012·Medicine and Science in Sports and Exercise·Diane M Dellavalle, Jere D Haas
Mar 4, 2010·European Journal of Clinical Nutrition·S Mettler, M B Zimmermann
Jul 10, 2010·Journal of Renal Care·Donald S SilverbergDoron Schwartz
May 27, 2008·Journal of the International Society of Sports Nutrition·Melvin H Williams
Apr 24, 2014·Biological Trace Element Research·Takako SawadaKatsuhiko Yokoi
Aug 5, 2010·Journal of Pediatric Gastroenterology and Nutrition·Lise P M PelsPatrick F van Rheenen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.