Marginal zinc deficiency exacerbates bone lead accumulation and high dietary zinc attenuates lead accumulation at the expense of bone density in growing rats

Toxicological Sciences : an Official Journal of the Society of Toxicology
Jennifer A JamiesonHope A Weiler

Abstract

Environmental lead exposure is associated with reduced bone growth and quality, which may predispose to osteoporosis. Zinc supplementation may reduce lead accumulation; however, effects on bone development have not been addressed. Our objective was to investigate the effects of marginal zinc (MZ) and supplemental zinc (SZ) intakes on bone lead deposition and skeletal development in lead-exposed rats. In a factorial design, weanling Sprague-Dawley rats were assigned to MZ (8 mg/kg diet); zinc-adequate control (CT; 30 mg/kg); zinc-adequate, diet-restricted (DR; 30 mg/kg); or SZ (300 mg/kg) groups, with and without lead acetate-containing drinking water (200 mg Pb/l) for 3 weeks. Excised femurs were analyzed for bone mineral density (BMD) by dual-energy x-ray absorptiometry, morphometry, and mineral content. MZ had higher femur lead and lower femur zinc concentrations and impaired skeletal growth and mineralization than CT. DR inhibited growth but did not result in higher femur lead concentrations than CT. SZ had higher femur zinc and lower femur lead concentrations than the other treatments. DR and SZ had impaired BMD versus CT and MZ. Lead also retarded skeletal growth and impaired BMD, but an interaction between lead and MZ was...Continue Reading

References

May 1, 1976·The Journal of Nutrition·F L Cerklewski, R M Forbes
Feb 1, 1991·Environmental Health Perspectives·J G PoundsJ F Rosen
May 1, 1987·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·W VicteryR A Goyer
Jul 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J D Hamilton, E J O'Flaherty
Sep 1, 1996·Toxicology and Applied Pharmacology·D G HicksR N Rosier
Jul 7, 1999·The Journal of Pediatrics·J R SerwintW Rogan
Jul 14, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·M J RonisC K Lumpkin
Jun 18, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·M K Javaid, Cyrus Cooper
Jan 24, 2003·The New England Journal of Medicine·Ja-Liang LinChun-Chen Yu
Mar 27, 2004·Experimental Biology and Medicine·Heather J HoseaHope A Weiler
Aug 4, 2004·Environmental Health Perspectives·James R CampbellJ Edward Puzas
Apr 19, 2005·Journal of Inorganic Biochemistry·Debasis Bagchi, Harry G Preuss
Jun 1, 1981·Biological Trace Element Research·M S CleggL S Hurley

❮ Previous
Next ❯

Citations

Oct 19, 2010·Biological Trace Element Research·Jian-Yi SunXiao-Yan Weng
Jan 2, 2014·Indian Journal of Clinical Biochemistry : IJCB·Nilima N DongreBasavaraj B Devarnavadagi
May 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·June K DunnickGregory S Travlos
Apr 23, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sabiya AbbasNaibedya Chattopadhyay
Jun 19, 2013·International Journal of Applied & Basic Medical Research·Moses B EkongMonday I Akpanabiatu
Mar 29, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jennifer A JamiesonCarla G Taylor
Dec 23, 2015·International Journal of Molecular Sciences·Arif Tasleem JanQazi Mohd Rizwanul Haq
Jun 15, 2007·Toxicology·Malgorzata M BrzóskaJanina Moniuszko-Jakoniuk
Jan 11, 2011·Journal of the Science of Food and Agriculture·Jingjing JiaoYu Zhang
Sep 12, 2015·BioMed Research International·Anetta Zioła-FrankowskaMarcin Frankowski
Dec 25, 2012·Environmental Pollution·Jaime Rodríguez-EstivalRafael Mateo
Aug 9, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mary L S QueirozAndrana K Calgarotto
Mar 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu ZhangJingjing Jiao
Jun 17, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·A ModabberniaA Reichenberg
Feb 5, 2013·Chemico-biological Interactions·Elżbieta Kupraszewicz, Malgorzata M Brzóska
Mar 12, 2017·The Journal of Pediatrics·Katarzyna Kordas
Dec 25, 2008·Toxicology and Industrial Health·M A AlghazalP Váczi
Mar 7, 2018·Journal of Applied Toxicology : JAT·Edyta Andrulewicz-BotulińskaAnna Galicka
Jun 10, 2019·Environmental Science and Pollution Research International·Tao LiYaohua Dai
Feb 13, 2016·Current Opinion in Pediatrics·Amirhossein ModabberniaAbraham Reichenberg
Mar 20, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Ivana ZofkováPetr Matucha
Dec 9, 2010·Annals of Human Biology·Y Srinivasa ReddyB Dinesh Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.