PMID: 9446854Mar 7, 1998Paper

Marginal zinc deficiency lowers the lymphatic absorption of alpha-tocopherol in rats

The Journal of Nutrition
E S KimS I Koo

Abstract

The present study was conducted to investigate whether the intestinal absorption of vitamin E is influenced by marginal zinc deficiency. Rats trained to meal feed were divided into two groups and fed a diet containing 3 mg Zn/kg [a low zinc (LZ group)] or pair-fed (PF controls a zinc-adequate diet (30 mg Zn/kg). At 5 wk, the body weight (352 +/- 5 g, mean +/- SD) of LZ rats was 98.5% of that of PF rats (357 +/- 8 g). Rats with lymph cannula were infused at 3 mL/h via a duodenal catheter with a lipid emulsion consisting of 568 micromol triolein, 3.56 micromol alpha-tocopherol (alphaTP) and 396 micromol Na+-taurocholate in 24 mL of phosphate-buffered saline (pH 6.4). Lymph was collected hourly for 8 h. The amounts of alphaTP absorbed into the lymph were determined by high-performance liquid chromatography (HPLC). The hourly rate of alphaTP absorption was significantly lower in LZ than in PF rats. A marked difference (P < 0.05) was clearly evident even at 1 h (1.8 +/- 1.2 nmol/h in LZ vs. 8.5 +/- 3.0 nmol/h in PF). The peak rate of absorption was significantly lower in LZ rats (67.1 +/- 16.7 nmol/h at 5 h) than in PF rats (95.9 +/- 7.7 nmol/h at 4 h). The total amounts of alphaTP absorbed in 8 h in LZ and PF rats were 391.1 +/- 54...Continue Reading

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Citations

Jul 16, 1999·Lipids·S H HagemanR M Clark
Nov 13, 2009·Journal of Animal Physiology and Animal Nutrition·F KaradasM R Bedford
Nov 7, 2014·Cutaneous and Ocular Toxicology·Özlem BilgiçAli Ünlü
Apr 16, 1999·Journal of the American College of Nutrition·B HennigC J McClain
Sep 2, 2003·The Journal of Nutrition·Kazim Sahin, Omer Kucuk
Jul 28, 2001·Sports Medicine·A MichelettiS Rufini
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·A Van Gossum, J Neve
May 14, 2003·The Journal of Nutritional Biochemistry·Sang K Noh, Sung I Koo
Sep 6, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pavel Gershkovich, Amnon Hoffman
Dec 5, 2006·The Journal of Nutritional Biochemistry·Richard S BrunoEmily Ho

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