Marginal zone B-cells, a gatekeeper of innate immunity.

Frontiers in Immunology
Moncef Zouali, Yolande Richard

Abstract

To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B lymphocytes were initially thought to only play a role in the adaptive branch of immunity. However, a number of converging observations revealed that two B-cell subsets, marginal zone (MZ) and B1 cells, exhibit unique developmental and functional characteristics, and can contribute to innate immune responses. In addition to their capacity to mount a local antibody response against type-2 T-cell-independent (TI-2) antigens, MZ B-cells can participate to T-cell-dependent (TD) immune responses through the capture and import of blood-borne antigens to follicular areas of the spleen. Here, we discuss the multiple roles of MZ B-cells in humans, non-human primates, and rodents. We also summarize studies - performed in transgenic mice expressing fully human antibodies on their B-cells and in macaques whose infection with Simian immunodeficiency virus (SIV) represents a suitable model for HIV-1 infection in humans - showing that infectious agents have developed strategies to subvert MZ B-cell functions. In these two experimental models, we observed that two microbial superantigens for B-cells (protein...Continue Reading

Citations

May 21, 2013·FEBS Letters·Moncef Zouali
Sep 1, 2015·British Journal of Haematology·Ernest KucharMonika Karlikowska
Jan 21, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Erin JanssenRaif S Geha
Jan 19, 2018·Journal of Leukocyte Biology·Michael G Constantinides
Nov 6, 2018·ELife·Damián Pérez-MazliahJean Langhorne
Nov 21, 2018·Journal of Leukocyte Biology·Sandra Romero-RamírezJosé L Maravillas-Montero
Oct 17, 2014·Journal of Clinical and Experimental Hematopathology : JCEH·Rie TabataMasaru Kojima
Mar 8, 2019·PLoS Neglected Tropical Diseases·Stephen M ChristensenDavid M Mosser
Sep 4, 2020·Biological & Pharmaceutical Bulletin·Nehal E ElsadekTatsuhiro Ishida
Jul 1, 2020·Scandinavian Journal of Immunology·Dragan Marinkovic, Tatjana Marinkovic
Dec 16, 2016·The Journal of Biological Chemistry·Martijn van RosmalenMaarten Merkx
Oct 14, 2018·International Journal of Molecular Sciences·Niharika SinghSharmila Masli
Dec 17, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marta CuencaPablo Engel
Sep 2, 2020·BMC Neurology·Kostas PatasStylianos Chatzipanagiotou
Jun 13, 2014·Scandinavian Journal of Gastroenterology·Johanna SundinRobert J Brummer
Mar 25, 2019·Journal of Immunology Research·Zhihong ZhaoWeidong Cao
Aug 28, 2020·Frontiers in Immunology·Oliver NicolaiBarbara M Bröker
May 26, 2017·BMC Complementary and Alternative Medicine·Yakob P NagagiEliningaya J Kweka
Jun 21, 2020·Cellular Immunology·Jacqueline H Y SiuGavin J Pettigrew
Apr 21, 2020·Developmental and Comparative Immunology·Adef O KordonLesya M Pinchuk
Mar 1, 2021·Journal of Autoimmunity·Anna-Karin E Palm, Sandra Kleinau
May 11, 2021·Frontiers in Immunology·Manuel Sáez MoyaPablo Engel
Jul 17, 2021·Frontiers in Cellular and Infection Microbiology·Jorge A SotoAlexis M Kalergis
Jul 27, 2021·Current Opinion in Immunology·Eirini SevdaliHermann Eibel
May 22, 2020·Immunology Letters·Júlia Teixeira Cottas de Azevedo, Kelen Cristina Ribeiro Malmegrim

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Methods Mentioned

BETA
transgenic
PCR

Software Mentioned

MARCO

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