Margins and survival in oral cancer

The British Journal of Oral & Maxillofacial Surgery
D A MitchellT K Ong

Abstract

In the surgical management of oral squamous cell carcinoma (SCC) we aim to resect the tumour with clear margins in all planes. The aim of this study was to identify and compare overall survival in a group of 591 patients who had resections, and to relate this to the clearance of margins at the tumour bed. We used life tables to calculate survival at one, two, three, five, and 10 years after diagnosis by margin (clear=5mm or more; close=2-5mm; and involved=less than 2mm). Kaplan-Meier curves were produced for the margins alone, which were defined as clear in 480 patients (81%), close in 63 (11%), and involved in 48 (8%). Five-year survival was 81%, 75%, and 54% for clear, close, and involved margins, respectively, which highlights the importance of clear margins for survival. There is a significant prognostic implication associated with close, and particularly with involved, margins.

Citations

Jun 23, 2020·Acta Oto-laryngologica·Alexandra BungumChristian von Buchwald
May 8, 2019·Scientific Reports·Dong Wook KimHyung Jun Kim
Feb 20, 2020·Oral Diseases·Jasper VonkMax Johannes Hendrikus Witjes
Jun 27, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mark JakobJulia Kitz
Feb 14, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Joseph SolomonShamir P Chandarana
Mar 22, 2021·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Edward NguyenThasvir Singh
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May 26, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Pieter Jan SteinkampMax Johannes Hendrikus Witjes

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