PMID: 1208625Sep 1, 1975Paper

Marihuana-like activity of new synthetic tetrahydrocannabinols

Pharmacology, Biochemistry, and Behavior
B R MartinJ Beckner

Abstract

11-Methy-delta8-, 9-nor-delta8, and 9-nor-delta9-tetrahydrocannabinol (THC), newly synthesized cannabinoids which are not 11-hydroxyated in vivo, were tested for cannabinoid activity. Delta8-, delta9-THC and each synthetic analog produced static ataxia in unanesthetized dogs, hypotension and bradycardia in anesthetized dogs, and decreased spontaneous activity in mice. All synthetic analogs tested produced a greater degree of tolerance to the behavioral effect in dogs than did delta8-THC. 11-Methyl-delta8-THC was more effective than delta8-THC in decreasing spontaneous activity in mice, but was less active in producing the behavioral and cardiovascular effects in dogs. 9-nor-delta9-THC was less active than delta9-TCH, but 9-nor-delta8-THC was as active as delta8-THC in all observations. These results suggest that the 11-hydroxy metabolites of delta8- and delta 9-THC are not solely responsible for the biological activity of tetrahydrocannabinol.

Citations

May 28, 2005·Pharmacology, Biochemistry, and Behavior·Sara GonzálezJavier Fernández-Ruiz
Dec 7, 2000·Chemistry and Physics of Lipids·A D KhanolkarA Makriyannis
Sep 1, 1980·Journal of Ethnopharmacology·J J Kettenes-van den BoschI Khan
Sep 30, 2016·BMC Pharmacology & Toxicology·Joseph FriedrichG Ian Gallicano
Sep 1, 1975·Journal of Toxicology and Environmental Health·H RosenkrantzH J Esber

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