PMID: 1200773Dec 1, 1975Paper

Marijuana consumption and tolerance to physiological and subjective effects

Archives of General Psychiatry
T F BaborJ C Kuehnle

Abstract

The relation between marijuana consumption and the development of tolerance was investigated during a 31-day study. Volunteers with a history of moderate or heavy marijuana use were given access to one-gram (2.1% delta9 tetrahydrocannabinol [THC]) marijuana cigarettes during a 21-day smoking period. Both groups tended to increase consumption during this time. Heavy users averaged 5.7 cigarettes per day and indicated a progressive decline in ratings of intoxication and duration of pulse rate effect. Moderate users averaged 3.2 cigarettes per day but showed no changes in either of these reactions during this time. Results suggested that tolerance does not develop to the two most reliable indexes of marijuana intoxication unless heavy doses of delta9 THC are self-administered repeatedly. Also, the tendency to increase consumption during this time is not necessarily associated with the development of tolerance.

Citations

May 5, 2004·Experimental and Clinical Psychopharmacology·Tammy ChungJames W Langenbucher
Jan 1, 1984·Psychopharmacology·B W LexN K Mello
Oct 20, 1976·Psychopharmacology·T F BaborJ Kuehnle
Nov 1, 1991·Pharmacology, Biochemistry, and Behavior·M Perez-ReyesC E Cook
Aug 1, 1978·The International Journal of the Addictions·T F BaborJ C Kuehnle
Sep 1, 1980·Journal of Ethnopharmacology·J J Kettenes-van den BoschI Khan
Aug 19, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Evan C RosenbergOrrin Devinsky
Jun 1, 1996·Journal of Clinical Forensic Medicine·A BusuttilS Bulgin
Jan 1, 1976·Annals of the New York Academy of Sciences·R T JonesJ Bachman
Jan 1, 1976·Annals of the New York Academy of Sciences·A Wikler
Jan 1, 1978·The International Journal of the Addictions·T F BaborJ C Kuehnle
Jan 14, 2021·Current Treatment Options in Oncology·Mahmoud Abu-AmnaGil Bar-Sela
Feb 6, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J G RamaekersE L Theunissen

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