Marijuana effects on sensitivity to reinforcement in humans

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Scott D Lane, Don R Cherek

Abstract

Under controlled laboratory conditions, eight adult subjects smoked placebo and three different potencies of marijuana cigarettes ranging in Delta(9) THC content. Immediately following smoking, subjects were exposed to a laboratory task that provided concurrently available response options. One option systematically decreased in reinforcement frequency throughout the session, and thus required a reallocation of behavior to the non-decreasing option to maximize monetary earnings. After smoking the two highest doses (1.77% and 3.58% Delta(9) THC) subjects earned fewer reinforcers and allocated a higher proportion of responding to the decreasing option, compared with placebo and the lowest dose. The difference in reinforcers earned could not be accounted for by a change in response rates. Quantitative and graphical analyses revealed that the higher doses produced considerable periods of time spent on the decreasing option despite earning few reinforcers. The data are discussed with regard to marijuana effects on dopamine/cannabinoid systems and adaptive behavior change.

Citations

Jun 8, 2006·Experimental and Clinical Psychopharmacology·Scott D LaneJerome R Busemeyer
Sep 29, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert D RogersPetra Makela
Feb 24, 2006·Behavioural Pharmacology·Lori M LievingOleg V Tcheremissine
Apr 4, 2014·Psychopharmacology·Michael A P BloomfieldOliver D Howes
May 25, 2013·CNS Spectrums·Philip B MitchellCharles L Bowden
Nov 18, 2015·Psychopharmacology·Desirée B SpronkRobbert J Verkes
Apr 27, 2010·Journal of Mathematical Psychology·Daniel J FridbergJulie C Stout
Aug 26, 2006·Addictive Behaviors·Scott D LaneJennifer L Sharon
Apr 22, 2008·European Journal of Pharmacology·Tommy PattijAnton N M Schoffelmeer
Apr 19, 2005·Addictive Behaviors·Scott D LaneJoel L Steinberg
Mar 19, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott D LaneCythia J Pietras
Sep 16, 2016·Psychological Medicine·M A P BloomfieldO D Howes
Mar 15, 2005·Journal of the Experimental Analysis of Behavior·Scott D LaneOleg V Tcheremissine

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