Marijuana is not associated with progression of hepatic fibrosis in liver disease: a systematic review and meta-analysis

European Journal of Gastroenterology & Hepatology
Muhammad T FarooquiAijaz Ahmed

Abstract

An estimated 22 million adults use marijuana in the USA. The role of marijuana in the progression of hepatic fibrosis remains unclear. We carried out a systematic review and meta-analysis to evaluate the impact of marijuana on prevalence and progression of hepatic fibrosis in chronic liver disease. We searched several databases from inception through 10 November 2017 to identify studies evaluating the role of marijuana in chronic liver disease. Our main outcome of interest was prevalence/progression of hepatic fibrosis. Adjusted odds ratios (ORs) and hazards ratios (HRs) were pooled and analyzed using random-effects model. Nine studies with 5 976 026 patients were included in this meta-analysis. Prevalence of hepatic fibrosis was evaluated in nonalcoholic fatty liver disease (NAFLD), hepatitis C virus (HCV), and hepatitis C and HIV coinfection by two, four, and one studies. Progression of hepatic fibrosis was evaluated by two studies. Pooled OR for prevalence of fibrosis was 0.91 (0.72-1.15), I=75%. On subgroup analysis, pooled OR among NAFLD patients was 0.80 (0.75-0.86), I=0% and pooled OR among HCV patients was 1.96 (0.78-4.92), I=77%. Among studies evaluating HR, pooled HR for progression of fibrosis in HCV-HIV co-infected ...Continue Reading

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Jul 10, 2019·AIDS and Behavior·Melina Erica SantosUNKNOWN ANRS CO13 HEPAVIH Study Group
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Methods Mentioned

BETA
biopsy

Software Mentioned

EndNote
Ovid
Emtree
Ovid MEDLINE
Comprehensive Meta - analysis

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