Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders

Schizophrenia Research
Mary E KelleyMichael T Compton

Abstract

Several studies suggest that adolescent marijuana use predicts earlier age at onset of schizophrenia, which is a crucial prognostic indicator. Yet, many investigations have not adequately established a clear temporal relationship between the use and onset. We enrolled 247 first-episode psychosis patients from six psychiatric units and collected data on lifetime marijuana/alcohol/tobacco use, and ages at onset of prodrome and psychosis in 210 of these patients. Cox regression (survival analysis) was employed to quantify hazard ratios (HRs) for effects of diverse premorbid use variables on psychosis onset. Escalation of premorbid use in the 5years prior to onset was highly predictive of an increased risk for onset (e.g., increasing from no use to daily use, HR=3.6, p<0.0005). Through the analysis of time-specific measures, we determined that daily use approximately doubled the rate of onset (HR=2.2, p<0.0005), even after controlling for simultaneous alcohol/tobacco use. Building on previous studies, we were able to determine that cumulative marijuana exposure was associated with an increased rate of onset of psychosis (p=0.007), independent of gender and family history, and this is possibly the reason for age at initiation of mar...Continue Reading

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Citations

Oct 11, 2016·Annals of the New York Academy of Sciences·Esther K Choo, Sherry L Emery
Sep 14, 2016·Annual Review of Pharmacology and Toxicology·Nora D VolkowRuben D Baler
Jul 6, 2017·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Josiane BourquePatricia Conrod
Jan 16, 2018·Psychological Medicine·Alyson ZwickerRudolf Uher
Mar 21, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Antti MustonenJouko Miettunen
Oct 21, 2017·Early Intervention in Psychiatry·Michael L BirnbaumMichael T Compton
Feb 6, 2020·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jacob CookeyPhilip G Tibbo
Jun 13, 2020·Frontiers in Psychology·Marco ColizziSagnik Bhattacharyya
Jul 3, 2018·The Journal of Nervous and Mental Disease·Francesco BernardiniGwenolé Loas
Dec 20, 2018·European Archives of Psychiatry and Clinical Neuroscience·Darby J E LoweTony P George
Aug 20, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Natalie GoulterUNKNOWN Conduct Problems Prevention Research Group
Dec 9, 2020·Early Intervention in Psychiatry·Stephanie LangloisMichael T Compton
Apr 7, 2021·Psychiatric Services : a Journal of the American Psychiatric Association·Leah G PopeMichael T Compton

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