Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells.

Marine Drugs
Vicki EdwardsFiona Young

Abstract

Anticancer properties of tyrindoleninone and 6-bromoisatin from Dicathais orbita were tested against physiologically normal primary human granulosa cells (HGC) and reproductive cancer cell lines. Tyrindoleninone reduced cancer cell viability with IC₅₀ values of 39 µM (KGN; a tumour-derived granulosa cell line), 39 μM (JAr), and 156 μM (OVCAR-3), compared to 3516 μM in HGC. Apoptosis in HGC's occurred after 4 h at 391 µM tyrindoleninone compared to 20 µM in KGN cells. Differences in apoptosis between HGC and KGN cells were confirmed by TUNEL, with 66 and 31% apoptotic nuclei at 4 h in KGN and HGC, respectively. These marine compounds therefore have potential for development as treatments for female reproductive cancers.

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Citations

Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·T KaviarasanA Yogamoorthi
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Mar 22, 2014·Biotechnology and Applied Biochemistry·Vicki EdwardsFiona Young
Jun 24, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verónica Ruiz-TorresVicente Micol
Apr 6, 2018·Marine Drugs·Ashlin H TurnerChristina I Schroeder
Apr 10, 2019·Biochemistry·Cale C StreeterSteven M Firestine

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Methods Mentioned

BETA
Fluorescence
Assay

Software Mentioned

Masslynx
KC Junior

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