Marine natural products with monoamine oxidase (MAO) inhibitory activity.

Pharmaceutical Biology
Ahreum HongSang-Jip Nam

Abstract

Research interest in monoamine oxidase (MAO) as a promising drug target for neurodegenerative diseases has a long history. However, efforts to develop MAO inhibitors (MAOIs) from marine sources have been limited, despite the increasing number of interesting marine natural products. To review the potential of marine natural products as MAOIs source, including their activities and selectivity on MAO. Public databases such as SciFinder, MarinLit and PubMed were systematically searched from 1991 until Dec 2019. MAO and MAOI were the key terms searched combined with marine natural products and marine. Six classes of marine natural products with good selectivity between the two MAO subtypes were organized with their selectivity and sources. This is the first review to investigate the potential of marine natural products as MAOIs source. Despite the small number of known MAOIs from marine sources, marine natural products are potential leads for the further development of MAOI drugs with novel chemical frames and good selectivity.

References

Oct 11, 1985·Science·K N WestlundC W Abell
Mar 1, 1973·The Journal of Antibiotics·T TakeuchiK Ukita
Mar 1, 1982·Clinical and Experimental Pharmacology & Physiology·J Baird-LambertK M Taylor
Apr 15, 1999·Annual Review of Neuroscience·J C ShihM J Ridd
Jan 1, 1956·The American Journal of Psychiatry·G E CRANE
Jul 29, 2004·Current Medicinal Chemistry·J C Shih, K Chen
Oct 29, 2005·Journal of Natural Products·Nathaniel L Segraves, Phillip Crews
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Se-Young SonTomitake Tsukihara
Jul 15, 2009·Marine Drugs·Dobroslawa Bialonska, Jordan K Zjawiony
Jun 18, 2010·Expert Opinion on Therapeutic Patents·Adriana BolascoRossella Fioravanti
Oct 25, 2011·Biomolecular Concepts·Helena Gaweska, Paul F Fitzpatrick
Sep 11, 2012·American Journal of Therapeutics·Saleem K Al-NuaimiGlen B Baker
May 15, 2013·Marine Drugs·Luiz Henrique Agra Cavalcante-SilvaMagna Suzana Alexandre-Moreira
Aug 13, 2013·CNS Drugs·Kenneth I ShulmanScott E Walker
Dec 24, 2013·Current Topics in Medicinal Chemistry·Rajesh RaneRajshekhar Karpoormath
May 7, 2014·Chemical Biology & Drug Design·Rajesh A RaneRajshekhar Karpoormath
Dec 3, 2014·Journal of Natural Products·Hiyoung KimHeonjoong Kang
Jun 3, 2015·Journal of Microbiology and Biotechnology·Hyun Woo LeeHoon Kim
Nov 13, 2015·Current Pharmaceutical Design·Ilkay Erdogan Orhan
Jan 10, 2017·Journal of Microbiology and Biotechnology·Hyun Woo LeeHoon Kim
Jan 27, 2017·CNS & Neurological Disorders Drug Targets·Livia Dezsi, Laszlo Vecsei

❮ Previous
Next ❯

Citations

Jun 9, 2021·Journal of Microbiology and Biotechnology·Jong Min OhHoon Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
deamination

Software Mentioned

Moldock
DRAGON

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.