Marine omega-3 fatty acids and coronary heart disease

Current Opinion in Cardiology
Philip C Calder, Parveen Yaqoob

Abstract

To provide an overview of the key earlier intervention studies with marine omega-3 fatty acids and to review and comment on recent studies reporting on mortality outcomes and on selected underlying mechanisms of action. Studies relating marine omega-3 fatty acid status to current or future outcomes continue to indicate benefits, for example, on incident heart failure, congestive heart failure, acute coronary syndrome, and all-cause mortality. New mechanistic insights into the actions of marine omega-3 fatty acids have been gained. Three fairly large secondary prevention trials have not confirmed the previously reported benefit of marine omega-3 fatty acids towards mortality in survivors of myocardial infarction. Studies of marine omega-3 fatty acids in atrial fibrillation and in cardiac surgery-induced atrial fibrillation have produced inconsistent findings and meta-analyses demonstrate no benefit. A study confirmed that marine omega-3 fatty acids reduce the inflammatory burden with advanced atherosclerotic plaques, so inducing greater stability. Recent studies of marine omega-3 fatty acids on morbidity of, and mortality from, coronary and cardiovascular disease have produced mixed findings. These studies raise new issues to be...Continue Reading

References

Nov 22, 1980·Lancet·A HiraiJ Jajiki
Jul 27, 1999·The American Journal of Cardiology·J Plutzky
Nov 20, 2002·Circulation·Penny M Kris-EthertonUNKNOWN American Heart Association. Nutrition Committee
Jun 26, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Kristof VanschoonbeekJohan W M Heemskerk
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
May 17, 2005·Journal of the American College of Cardiology·Leonardo CalòMassimo Santini
Aug 20, 2005·Trends in Immunology·John M HallenbeckKyra J Becker
Nov 4, 2005·Circulation·Alexander LeafUNKNOWN Fatty Acid Antiarrhythmia Trial Investigators
Aug 22, 2006·The American Journal of Cardiology·James A Reiffel, Arline McDonald
Apr 3, 2007·Lancet·Mitsuhiro YokoyamaUNKNOWN Japan EPA lipid intervention study (JELIS) Investigators
Dec 28, 2007·Atherosclerosis·William S HarrisErnst J Schaefer
Aug 2, 2008·Journal of the American College of Cardiology·Akira SekikawaUNKNOWN ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort
May 8, 2009·PloS One·Gregory C ShearerWilliam S Harris
Nov 27, 2009·Postgraduate Medicine·Philip C Calder, Parveen Yaqoob
Jan 12, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ragnhildur HeidarsdottirOlafur S Indridason
May 21, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuichi IshikawaUNKNOWN JELIS Investigators
Jul 20, 2010·Lancet·Palaniappan SaravananPhilip C Calder
Oct 12, 2010·The New England Journal of Medicine·Daan KromhoutUNKNOWN Alpha Omega Trial Group
Nov 10, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Leopoldo BianconiMassimo Santini
Nov 26, 2010·Journal of Atherosclerosis and Thrombosis·Hiroshige ItakuraUNKNOWN JELIS Investigators
Dec 1, 2010·BMJ : British Medical Journal·Pilar GalanUNKNOWN SU.FOL.OM3 Collaborative Group
Mar 29, 2011·The Annals of Thoracic Surgery·Umberto BenedettoRiccardo Sinatra

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Citations

Nov 5, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Jenifer I FentonEric A Gurzell
Jan 5, 2014·Lipids in Health and Disease·Peter D NicholsMahinda Abeywardena
Apr 12, 2016·Drugs & Therapy Perspectives : for Rational Drug Selection and Use·Richard S Castaldo
Aug 21, 2013·Journal of Food Science·Ioannis Zabetakis
May 6, 2015·Breast Cancer Research : BCR·Carol J FabianStephen D Hursting
Nov 5, 2016·Progress in Lipid Research·Ella J BakerPhilip C Calder
Mar 31, 2018·Nutrients·Marcelo Macedo Rogero, Philip C Calder
Dec 27, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C Calder, Richard J Deckelbaum
Oct 17, 2018·Canadian Journal of Physiology and Pharmacology·Ahmed M DarweshJohn M Seubert
Oct 19, 2017·The Proceedings of the Nutrition Society·P C Calder
Jan 23, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Philip C Calder, Richard J Deckelbaum
Feb 23, 2020·International Journal of Molecular Sciences·Jacqueline K Innes, Philip C Calder
Jun 27, 2019·The Cochrane Database of Systematic Reviews·Celia Gabriela Alvarez CampanoFrank Thies
May 10, 2019·Biotechnology Letters·Xiuwen WangXingguo Wang
Jan 31, 2021·European Journal of Clinical Nutrition·Linda TramKim Overvad

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