Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities.

Chemistry & Biodiversity
Sabrin R M Ibrahim, Gamal A Mohamed

Abstract

Pyridoacridines are a class of strictly marine-derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti-HIV, and anti-parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment.

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Citations

Aug 23, 2020·Antibiotics·Marcello CasertanoConcetta Imperatore
May 15, 2018·Marine Drugs·Dianne J Watters
Oct 15, 2021·The Journal of Organic Chemistry·Dongfang Jiang, Shaozhong Wang

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