Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.

Marine Drugs
Sébastien DeslandesEvelyne Delfourne

Abstract

Granulatimide and isogranulatimide are alkaloids obtained from marine sources which have been shown to inhibit cell-cycle G2-checkpoint, targeting more particularly checkpoint 1 kinase (Chk1). At a structural level, they possess a characteristic pyrrolocarbazole framework also shared by the well-known rebeccamycin and staurosporine microbial metabolites which have been described to inhibit topoisomerase I and diverse kinases, respectively. This review reports precisely on the synthesis and kinase inhibitory activities of pyrrolocarbazole-based analogues of granulatimide.

References

Jul 1, 1995·The Journal of Antibiotics·S OmuraH Takeshima
Mar 17, 1999·Journal of Natural Products·H C VervoortP A Keifer
Dec 23, 1999·Medicinal Research Reviews·C García-EcheverríaD B Evans
Jan 14, 2000·Journal of Medicinal Chemistry·T M SieleckiG L Trainor
Dec 15, 2000·Oncogene·F A Al-Obeidi, K S Lam
Feb 24, 2001·Pharmaceutical Research·R SridharD R Cooper
Oct 19, 2001·Medicinal Research Reviews·P L Toogood
Oct 19, 2001·Medicinal Research Reviews·P TraxlerJ Zimmermann
Oct 24, 2001·The Journal of Organic Chemistry·Margaret M. FaulChristine A. Krumrich
Dec 26, 2001·Chemical Reviews·A J Bridges
Jun 5, 2002·Chemical & Pharmaceutical Bulletin·Takuji YoshidaEiichi Kotani
Jun 6, 2002·Drug Discovery Today·Giovanna Scapin
Sep 24, 2002·The Journal of Biological Chemistry·Baoguang ZhaoBin-Bing S Zhou
Dec 10, 2002·Science·G ManningS Sudarsanam
Feb 7, 2003·Journal of Medicinal Chemistry·Christelle MarminonMichelle Prudhomme
Feb 11, 2003·Chemical & Pharmaceutical Bulletin·Takuji YoshidaEiichi Kotani
Mar 27, 2003·Bioorganic & Medicinal Chemistry Letters·Guoxin ZhuScott A Watkins
Jun 26, 2003·Bioorganic & Medicinal Chemistry Letters·Thomas A EnglerMichelle L Lytle
Aug 7, 2003·Bioorganic & Medicinal Chemistry·Fabrice AnizonMichelle Prudhomme
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Concha Sanchez-MartinezJill Wagner
Apr 24, 2004·The Journal of Organic Chemistry·Margaret M FaulJames E Ray
May 20, 2004·Bioorganic & Medicinal Chemistry Letters·Guoxin ZhuMichelle L Lytle
May 20, 2004·Bioorganic & Medicinal Chemistry Letters·Rima S Al-awarSajan Joseph
Oct 21, 2004·Journal of the American Chemical Society·Howard BregmanEric Meggers
Dec 8, 2004·Current Medicinal Chemistry. Anti-cancer Agents·Michelle Prudhomme
Feb 16, 2005·Nature Biotechnology·Miles A FabianDavid J Lockhart
Mar 3, 2005·Angewandte Chemie·Douglas S WilliamsEric Meggers
Mar 4, 2005·Journal of Medicinal Chemistry·Sylvain RoutierDaniel-Henry Caignard
Apr 2, 2005·Journal of Medicinal Chemistry·Guisheng ZhangPeng George Wang
May 25, 2005·Bioorganic & Medicinal Chemistry Letters·Takahiro HosoyaMasami Ishibashi
Nov 18, 2005·Bioorganic & Medicinal Chemistry Letters·Ming TaoRobert L Hudkins
Jan 20, 2006·Journal of Medicinal Chemistry·Sylvain RoutierLaurent Meijer
Jul 22, 2006·Chembiochem : a European Journal of Chemical Biology·G Ekin Atilla-GokcumenEric Meggers
Dec 1, 2006·European Journal of Pharmacology·Hélène HénonMichelle Prudhomme

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Citations

Nov 11, 2011·Marine Drugs·Danielle SkropetaAna Zivanovic
Sep 24, 2014·Organic & Biomolecular Chemistry·Kuldeep Singh RathoreSreenivas Katukojvala
Apr 8, 2011·Natural Product Reports·Zhong Jin
Jul 20, 2012·European Journal of Medicinal Chemistry·Sébastien DeslandesEvelyne Delfourne
Mar 26, 2013·European Journal of Medicinal Chemistry·Manisha JunejaDevarajan Karunagaran
Oct 26, 2016·The Journal of Organic Chemistry·Moumita JashChinmay Chowdhury
May 15, 2018·Marine Drugs·Dianne J Watters
Apr 9, 2021·Bioorganic & Medicinal Chemistry Letters·Shiyang ZhouGuangying Chen

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Methods Mentioned

BETA
glycosylation
xenograft
flow cytometry

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