Marinopyrroles: Unique Drug Discoveries Based on Marine Natural Products

Medicinal Research Reviews
Rongshi Li

Abstract

Natural products provide a successful supply of new chemical entities (NCEs) for drug discovery to treat human diseases. Approximately half of the NCEs are based on natural products and their derivatives. Notably, marine natural products, a largely untapped resource, have contributed to drug discovery and development with eight drugs or cosmeceuticals approved by the U.S. Food and Drug Administration and European Medicines Agency, and ten candidates undergoing clinical trials. Collaborative efforts from drug developers, biologists, organic, medicinal, and natural product chemists have elevated drug discoveries to new levels. These efforts are expected to continue to improve the efficiency of natural product-based drugs. Marinopyrroles are examined here as a case study for potential anticancer and antibiotic agents.

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Citations

May 24, 2016·Marine Drugs·Nelson G M GomesAlexander Kornienko
Jun 4, 2020·Antibiotics·Maria Valeria RaimondiPatrizia Cancemi
May 19, 2019·Pharmaceutical Research·Thomas LaneSean Ekins
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Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wafaa N AldhafiriDaryl J Murry
Sep 25, 2019·Journal of Medicinal Chemistry·Jean A BernatchezRongshi Li

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