Marked difference in pathophysiology between tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats

Critical Care Medicine
Hidesaku AsakuraShinji Nakao

Abstract

Tissue factor and lipopolysaccharide frequently have been used to induce disseminated intravascular coagulation in experimental animal models. Although the pathophysiology of disseminated intravascular coagulation may differ according to the agents used to induce it, these previous models have not distinguished between the use of different disseminated intravascular coagulation-inducing agents. In this study, we attempted to evaluate the characteristic features of these agents in two types of disseminated intravascular coagulation models, with special reference to selected hemostatic parameters and pathologic findings in the kidney. Prospective, comparative, experimental study. Laboratory at a university hospital. Twenty-seven male Wistar rats, age 6-7 wks, weighing 160-170 g. Three groups of animals were studied: a control group (n = 8) receiving physiologic saline, a tissue factor-treated group (n = 11) receiving tissue factor 3.75 units/kg, and a lipopolysaccharide-treated group (n = 8) receiving lipopolysaccharide 30 mg/kg; each group sustained infusion for 4 hrs via the tail vein. The degree of hemostatic activation in both types of experimental disseminated intravascular coagulation was identical, based on the results of ...Continue Reading

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Citations

Apr 12, 2003·Critical Care Medicine·Wolfram Ruf, Matthias Riewald
Nov 23, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Toshihiro Kaneko, Hideo Wada
Mar 10, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hiroko SatoKimimasa Takahashi
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Jan 10, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hsin-Jung TsaiChin-Chen Wu
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hidesaku AsakuraShinji Nakao
Nov 15, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hsin-Jung TsaiChin-Chen Wu

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