Marked differences in frequencies of statin therapy relevant SLCO1B1 variants and haplotypes between Roma and Hungarian populations

BMC Genetics
Agnes NagyBela Melegh

Abstract

SLCO1B1 polymorphisms are relevant in statin pharmacokinetics. Aim of this study was to investigate the genetic variability and haplotype profile of SLCO1B1 polymorphisms in Roma and Hungarian populations. Genotypes of 470 Roma and 442 Hungarian subjects for c.388A > G, c.521T > C and c.1498-1331T > C polymorphisms were determined by PCR-RFLP assay. Using these SNPs eight different haplotypes could be differentiated. Differences were found between Roma and Hungarians in SLCO1B1 388AA (24.5 vs. 45.5 %), GG (33.4 vs. 17.9 %) genotypes, AG + GG (75.5 vs. 54.5 %) carriers, in G allele frequency (0.545 vs. 0.362), respectively (p < 0.001). The most common SLCO1B1 haplotype was the ht8 (GTT) both in Roma (43.6 %) and in Hungarian (59.1 %) samples. The ht6 (GCT) was not present in Roma population samples Haplotype analyses showed striking differences between the Roma and Hungarian samples in ht4 (ATT, 37.2 % vs 20.8 %), ht5 (GCC, 1.15 % vs. 3.62 %) and ht8 (GTT, 43.6 % vs. 59.1 %) haplotypes (p < 0.01), respectively. Linkage disequilibrium analysis showed that the studied variants are in different linkage disequilibrium patterns depending on the ethnic origin. Similarly to Caucasians the 388G is the minor allele in Hungarians, however...Continue Reading

References

Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J KönigD Keppler
Feb 9, 2000·Pharmacology & Therapeutics·A CorsiniF Bernini
Apr 26, 2000·The Journal of Biological Chemistry·J KönigD Keppler
Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Apr 12, 2001·BMC Medical Genetics·L KalaydjievaF Calafell
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Aug 24, 2004·American Journal of Human Genetics·Bharti MorarLuba Kalaydjieva
Dec 21, 2006·Pharmaceutical Research·Kari T Kivistö, Mikko Niemi
Dec 23, 2006·International Journal of Legal Medicine·Jodi IrwinThomas J Parsons
Jul 11, 2007·Current Opinion in Lipidology·Lara M Mangravite, Ronald M Krauss
Jul 10, 1908·Science·G H Hardy
Feb 5, 2008·Pharmacogenomics·Mikko Niemi
Jul 25, 2008·The New England Journal of Medicine·UNKNOWN SEARCH Collaborative GroupR Collins
Jun 17, 2009·The Pharmacogenomics Journal·E ZintzarasG Raman
Sep 30, 2009·British Journal of Pharmacology·A Kalliokoski, M Niemi
Nov 4, 2009·The Pharmacogenomics Journal·S P R RomaineA J Balmforth
Dec 3, 2009·Pharmacogenetics and Genomics·Connie OshiroRuss Altman
Sep 20, 2011·European Journal of Clinical Pharmacology·Paulo Caleb Junior Lima SantosAlexandre Costa Pereira
May 9, 2012·Molecular Medicine Reports·Ling-Min LiWen-Sheng Chen
May 15, 2012·Pediatric Research·Laura Alencastro de AzevedoUrsula Matte
May 16, 2012·Journal of Clinical Pharmacy and Therapeutics·M Francesca NotarangeloD Ardissino
May 24, 2012·Clinical Pharmacology and Therapeutics·R A WilkeUNKNOWN Clinical Pharmacogenomics Implementation Consortium (CPIC)
May 28, 2013·American Heart Journal·Jacqueline S DanikPaul M Ridker
May 21, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jaroslav A HubáčekMichal Vrablík

❮ Previous
Next ❯

Citations

Feb 10, 2018·Journal of Clinical Laboratory Analysis·Zhixiong ZhongPingsen Zhao
Nov 20, 2018·PloS One·Tatjana Škarić-JurićMarijana Peričić Salihović
Jun 23, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Rene de BeerPrashilla Soma
Jul 6, 2021·Frontiers in Genetics·Neus Font-PorteriasDavid Comas

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

SPSS
Excel
Haploview
PHASE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.