Marked differences in functioning of the hypothalamic-pituitary-adrenal axis between groups of men

Journal of Applied Physiology
J S PetridesP A Deuster

Abstract

To compare profiles of hypothalamic-pituitary-adrenal (HPA) responsiveness, healthy, moderately trained men (n = 15) were classified as high (n = 7) or low responders (n = 8) on the basis of plasma adrenocorticotropic hormone (ACTH) responses to strenuous treadmill exercise 4 h after 4 mg of dexamethasone (Dex). These groups were then evaluated to compare 1) HPA and growth hormone responses to exercise at 90% maximal oxygen uptake 4 h after placebo, Dex (4 mg), and hydrocortisone (100 mg); 2) pituitary-adrenal responses to infusion of arginine vasopressin (AVP); 3) plasma cortisol after a Dex suppression test (1 mg); and 4) behavioral characteristics. In comparison to low responders, high responders exhibited significantly 1) higher plasma ACTH responses to exercise after placebo and Dex; 2) higher plasma AVP secretion with exercise after placebo and marked Dex- and hydrocortisone-induced enhancement of exercise-induced AVP secretion; 3) lower Dex-induced increases in basal and stimulated growth hormone secretion; 4) higher plasma ACTH responses to infusion of AVP; and 5) a trend (P = 0.09) for higher trait anxiety ratings. Similar suppression of plasma cortisol was noted after 1 mg Dex. We conclude that subgroups of healthy ma...Continue Reading

References

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Citations

Feb 28, 2002·Annual Review of Immunology·Jeanette I WebsterEsther M Sternberg
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Martine DuclosYves Le Bouc
Sep 23, 2009·Clinical Endocrinology·Femke RuttersMargriet S Westerterp-Plantenga
Oct 21, 2010·The Physician and Sportsmedicine·Martine Duclos
Jul 22, 2019·British Journal of Sports Medicine·Alan VernecChristian J Strasburger
Dec 29, 1999·Medicine and Science in Sports and Exercise·P A DeusterE M Sternberg
Sep 8, 1998·Journal of Applied Physiology·W J InderR A Donald
Sep 27, 2008·Journal of Clinical Biochemistry and Nutrition·Keiichi HiramotoMasayasu Inoue
Sep 7, 2007·Medicine and Science in Sports and Exercise·Alexandre ArlettazKatia Collomp
Jun 17, 1998·Endocrine Reviews·E R De KloetM Joëls
Oct 7, 2014·Interface Focus·Marni N Silverman, Patricia A Deuster
Jun 18, 1999·The Journal of Clinical Endocrinology and Metabolism·A SinghP A Deuster
Aug 19, 2007·Brain Research Reviews·Nuno SousaOsborne F X Almeida

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