Marked disparity in mechanical wall properties between ascending and descending aorta in patients with tetralogy of Fallot

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Hirofumi SaikiHideaki Senzaki

Abstract

Recent studies have linked abnormal aortic medial pathology to progressive aortic root dilatation in patients with tetralogy of Fallot (TOF). To explore whether the aortic medial pathology in TOF is linked to aortic mechanical property, the present study tested the hypothesis that the distribution of impaired aortic elasticity corresponds to the known distribution of abnormal medial pathology (confined to the ascending aorta) in TOF. Pulse wave velocity (PWV) of the proximal and distal aortas was measured with a high-fidelity micromanometer in 98 TOF patients (64 with repaired TOF and 34 with unrepaired TOF) and 63 control subjects. PWV of the proximal aorta was significantly higher in TOF than in the control, but similar in repaired and unrepaired TOF (repaired: 588 ± 205 cm/s, unrepaired: 680 ± 288 cm/s, control: 439 ± 101 cm/s, P < 0.001 for each TOF group vs. control, P = 0.07 for repaired vs. unrepaired TOF). In contrast, PWV of the distal aorta was almost identical among the three groups (repaired: 441 ± 189 cm/s, unrepaired: 430 ± 114 cm/s, control: 461 ± 164 cm/s, P = 0.73, analysis of variance), indicating that abnormal aortic mechanical property is confined to the proximal aorta regardless of the operative status of T...Continue Reading

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Citations

Feb 10, 2016·American Heart Journal·Hirofumi SaikiHideaki Senzaki
Aug 12, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Takuro KojimaHideaki Senzaki
Jan 27, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuru SekiHideaki Senzaki
Jan 10, 2018·Cardiology in the Young·Chaitanya PanchangamGeetha Raghuveer
Jul 15, 2015·Hypertension·Raymond R TownsendUNKNOWN American Heart Association Council on Hypertension
Mar 16, 2019·Journal of the American Heart Association·Alexander C EgbeHeidi M Connolly
Nov 28, 2013·Current Opinion in Cardiology·Abigail May Khan, Yuli Kim
Oct 17, 2020·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Krithika RamaprabhuBashi Velayudhan
Apr 17, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Tomoaki MurakamiKoichiro Niwa
Aug 24, 2021·Heart, Lung & Circulation·Kieran SandhuJonathan P Mynard

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