Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker

Annals of Surgery
J S GoydosS E Carty

Abstract

To determine if the serum level of interleukin-6 (IL-6) was elevated in patients with hepatic malignancies or correlated with radiologic tumor burden. High serum levels of IL-6 signify an adverse prognosis in many patients with cancer. IL-6 is a growth factor for bile duct epithelium. Using bioactive and enzyme-linked immunosorbent assays, serum level of IL-6 was measured in 35 healthy adults and in 60 patients presenting for definitive management of cholangiocarcinoma (CC) (15 patients), hepatocellular carcinoma (HCC) (14), metastatic colorectal cancer (MCRC) (26), and benign biliary disease (BBD) (5). Patients with clinical conditions known to raise the serum level of IL-6 were excluded. Tumor burden was calculated from concurrent computed tomography scans. IL-6 levels were measured 2 weeks after resection in 3 CC patients. Secretion of IL-6 was examined in 3 human CC cell lines. An elevated level of bioactive IL-6 was detected in every patient with CC and in 13 of 14 patients with HCC, 14 of 26 patients with MCRC, 2 of 5 patients with BBD, and 3 of 35 healthy adults. Median and mean levels of bioactive IL-6 were higher in CC than in other neoplasms (p < 0.026) and for all tumor groups differed from healthy adults (p < or = 0...Continue Reading

References

Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·Y ShimizuT L Whiteside
Jan 1, 1992·Life Sciences·J WeiG P Hemmings
Mar 1, 1992·British Journal of Cancer·O GalloR Abbate
Jan 1, 1992·Nephron·J M CavaillonS Delons
Jun 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M H BemelmansW A Buurman
Oct 1, 1990·Japanese Journal of Cancer Research : Gann·M KitaharaM Okada
Nov 1, 1990·Genes, Chromosomes & Cancer·P D StortoS M Gollin
Jan 1, 1989·Annals of the New York Academy of Sciences·L A Aarden
May 1, 1994·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·J WeberS A Rosenberg
Mar 1, 1995·Archives of Surgery·W K WashburnR L Jenkins
May 1, 1994·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·M RabauA Eisenthal
Mar 1, 1994·The Journal of Investigative Dermatology·C A ArmstrongJ C Ansel
Aug 25, 1993·JAMA : the Journal of the American Medical Association·C G MoertelC Tangen
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C DosquetJ Cabane
Jan 1, 1993·Cancer Investigation·M Lotz
Feb 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A Rogers, D K Podolsky
Feb 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·A KatzL Eisenbach
Jul 1, 1993·Annals of Surgery·A C DrostB A Pruitt
Jan 1, 1993·The Annals of Thoracic Surgery·Y YoshidaB P Griffith

❮ Previous
Next ❯

Citations

Jun 30, 2009·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masahide IkeguchiShigeru Tatebe
Mar 29, 2001·Current Gastroenterology Reports·M Ortner
Jun 1, 2005·Biochimica Et Biophysica Acta·Tong Wu
Apr 26, 2003·Journal of Hepatology·Gregory J Gores
Jul 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tong WuA Jake Demetris
Oct 28, 1999·The New England Journal of Medicine·P C de GroenD M Nagorney
Oct 7, 2006·Current Opinion in Gastroenterology·J A Ehrenfried, J N Vauthey
Oct 23, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gabriel FramptonSharon DeMorrow
Mar 11, 2011·Lipids in Health and Disease·Apinya JusakulRahul Kuver
Nov 26, 2008·World Journal of Gastroenterology : WJG·Yucel Ustundag, Yusuf Bayraktar
Dec 17, 2008·World Journal of Gastroenterology : WJG·Alphonse-E Sirica
Feb 21, 2014·Seminars in Immunology·Koji Taniguchi, Michael Karin
Aug 27, 2013·Expert Opinion on Medical Diagnostics·James R A SkipworthStephen P Pereira
May 27, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M Grunnet, M Mau-Sørensen
Jul 28, 2005·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P Guillem, J P Triboulet
Mar 20, 2004·Clinical and Experimental Immunology·S A SafleyC J Weber
Oct 28, 2011·Clinical Science·Masahiko MiharaMasashi Shiina
Jul 17, 2001·The Tohoku Journal of Experimental Medicine·S MimasakaM Funayama
May 28, 2016·Biomarkers in Medicine·Bin WangHao-Teng Chang
Jul 3, 2013·ISRN Oncology·Maria E Ramos-Nino
Aug 18, 2009·Photodiagnosis and Photodynamic Therapy·Ron R AllisonClaudio H Sibata
Oct 7, 2016·Clinical and Translational Medicine·Sven H LoosenTom Luedde
Sep 28, 2007·The American Journal of Gastroenterology·Justin L Mott, Gregory J Gores
Jul 30, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Claudio PintoMarco Marzioni
Dec 17, 2017·Journal of Gastroenterology and Hepatology·Surachate SiripongsakunChulabhorn Mahidol
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ParkT Patel
Mar 30, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J ParkT Patel
Apr 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gregory J Gores
Jun 7, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Boris Blechacz, Gregory J Gores
Dec 24, 2010·The Korean Journal of Internal Medicine·Young Koog Cheon
Dec 1, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hajime IsomotoGregory J Gores

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.