PMID: 3764530Oct 1, 1986Paper

Marked hypochloremic metabolic alkalosis with severe compensatory hypoventilation

Southern Medical Journal
C J LavieT G Ferguson

Abstract

In metabolic alkalosis, a compensatory decrease in alveolar ventilation with hypercapnia has been noted only rarely. We recently managed a patient with gastric outlet obstruction from a duodenal ulcer who survived after arriving in the emergency room comatose with severe hypochloremic metabolic alkalosis, compensatory hypoventilation, and hypercapnia. We know of no report in the English literature of a patient with gastric outlet obstruction having a respiratory acidosis or hypochloremia as severe as that in our patient. Proper understanding of the pathophysiology of primary metabolic alkalosis due to gastric losses is necessary to correct the acid-base abnormalities quickly and to restore normal alveolar ventilation.

Citations

Jun 16, 2012·TheScientificWorldJournal·Makiko TaniKiyoshi Morita
Oct 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J Perrone, R S Hoffman
Dec 16, 2006·The American Journal of the Medical Sciences·Meredith McCauleyMark J Cowan
Feb 15, 2013·The American Journal of Emergency Medicine·David P BettenBrent M Felton
Apr 1, 1988·Annals of Emergency Medicine·M Mennen, C M Slovis
Jan 10, 2012·Air Medical Journal·Cody R Tigges, Michael T Bigham
Jan 16, 2007·Critical Care : the Official Journal of the Critical Care Forum·Udo ReulbachStefan Bleich
Sep 26, 2019·American Journal of Respiratory and Critical Care Medicine·Alberto ZanellaAntonio M Pesenti

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