Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-gamma-independent pathway following transient global ischemia in mouse

Neuroscience Research
Masato HoshiM Seishima

Abstract

Indoleamine 2, 3-dioxygenase (IDO), which catabolizes L-tryptophan (L-TRP) to L-kynurenine (L-KYN), is an immunoregulatory factor that is up-regulated via an interferon-gamma (IFN-gamma)-dependent and/or -independent mechanism. In this study, we investigated the localization of IDO and whether induction of IDO expression is an IFN-gamma-dependent and/or -independent mechanism in the CNS after cerebral ischemia. The expressions of IDO protein and mRNA were investigated at different time points following cerebral ischemia using immunohistochemistry, immunofluorescence and RT-PCR. Hippocampal neuron IDO mRNA and immunohistochemical staining were significantly up-regulated 72h after transient global ischemia. Although IFN-gamma is a dominant inducer of IDO, hippocampal neuron IDO was clearly up-regulated in IFN-gamma KO mice. In summary, this is the first finding that up-regulation of IDO in hippocampal neurons after transient global ischemia occurs via INF-gamma-independent mechanisms.

References

Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J GehrmannG W Kreutzberg
Apr 2, 1998·Journal of Neurochemistry·K M WaltonR V Bhat
May 6, 1999·Nature Medicine·A SchneiderM Schwaninger
Jan 5, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R GregersenB Finsen
May 3, 2000·Neuroreport·F BlockM Nolden-Koch
Sep 30, 2004·Journal of Neuropathology and Experimental Neurology·Kate Lykke LambertsenBente Finsen

❮ Previous
Next ❯

Citations

Mar 2, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Katherine A JackmanChristopher G Sobey
Apr 12, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rachel KennySarah J Spencer
Aug 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masato HoshiMitsuru Seishima
Jun 4, 2019·Journal of Neuroinflammation·Sara HemmatiAhmad Reza Dehpour

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.