PMID: 11914439Mar 27, 2002Paper

Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program

Psychosomatic Medicine
John W MasonSteven Southwick

Abstract

The objective of this study was to obtain longitudinal data on lability of cortisol levels in posttraumatic stress disorder (PTSD) because previous studies have largely been based on sampling at a single time point and have yielded varying results. This study measured urinary cortisol levels at admission, midcourse, and discharge during a 90-day hospitalization period in male Vietnam combat veterans with PTSD (N = 51). Although there were no significant differences in the mean +/- SEM urinary cortisol levels between the admission (59.4 +/- 3.0 microg/d), midcourse (55.6 +/- 3.9 microg/d), and discharge (53.4 +/- 3.4 microg/d) values, marked lability of cortisol levels in individual patients was observed over time, with changes ranging from +93 to -58 microg/d from admission to midcourse. In addition, this hormonal lability defined discrete subgroups of patients on the basis of the longitudinal pattern of cortisol change during exposure treatment, and there were significant psychometric differences in the level of social functioning between these subgroups. The findings do not support the concept of either a static "hypocortisolism" or "hypercortisolism" in PTSD, but rather suggest a psychogenic basis for cortisol alterations in...Continue Reading

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Citations

Apr 12, 2005·Neuroscience and Biobehavioral Reviews·Miranda OlffBerthold P R Gersons
Mar 11, 2008·Clinical Psychology Review·Gerald M Rosen, Scott O Lilienfeld
Feb 3, 2007·Neuroscience and Biobehavioral Reviews·Rianne Stam
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Oct 9, 2004·Psychoneuroendocrinology·Douglas L DelahantyMichele Walsh
May 29, 2015·Reviews in the Neurosciences·Anjana Bali, Amteshwar Singh Jaggi
Feb 26, 2014·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Serge BrandEdith Holsboer-Trachsler
Jun 25, 2013·Neuroscience and Biobehavioral Reviews·David V Baldwin
Mar 23, 2012·Palliative & Supportive Care·James K RustadM Beatriz Currier
Nov 14, 2017·Biological Research for Nursing·Ursula Ann KellyJessica Noggle Taylor
Feb 22, 2018·Journal of Traumatic Stress·Sarah C Hellewell, Ibolja Cernak
Jul 3, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bernet M ElzingaJ Douglas Bremner
Aug 8, 2006·Annals of the New York Academy of Sciences·Rachel Yehuda
Jun 9, 2007·Psychosomatic Medicine·Anja J E DirkzwagerC Joris Yzermans
Dec 5, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·Katja WingenfeldAndreas Hill
Jun 5, 2020·Journal of Dual Diagnosis·Yvette Z SzaboLaura Zambrano-Vazquez
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Jul 16, 2008·CNS Spectrums·Jyotsna Nair, Sarbjot Singh Ajit

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