Marked species and age-dependent differences in cell proliferation and neurogenesis in the hippocampus of wild-living rodents.

Hippocampus
Irmgard AmreinHans-Peter Lipp

Abstract

Variations in the extent of adult neurogenesis and natural and experimental factors controlling it have been described in laboratory animals. The wide range of variation seen even within a species, the mouse, raises the question as to which rates of neurogenesis can be expected in natural populations. Answering this question is important to evaluate the functional significance of adult neurogenesis under natural conditions and to define the factors controlling it. To address this issue, we investigated four species of wild-living rodents and outbred laboratory mice using markers for proliferating cells, Ki-67, and developing neurons, doublecortin and NeuroD. We found about four times as many Ki-67-positive cells per mm3 granule cell layer in two wood mouse species (Muridae; Apodemus spp.) than in bank and pine voles (Arvicolidae; Clethrionomys glareolus and Microtus subterraneus). Laboratory mice show proliferation rates between wood mice and voles. Markers for developing neurons, NeuroD and doublecortin, reflect the findings of proliferation activity. Hippocampal cell proliferation decreases dramatically with age in wild-living species. The onset of the downregulation varies among species. It occurs late in the life span of th...Continue Reading

References

May 1, 1978·Neuropathology and Applied Neurobiology·P D Lewis
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L F JacobsG E Hoffman
Feb 10, 1981·The Journal of Comparative Neurology·P Rakic, R S Nowakowski
Jan 1, 1994·Brain, Behavior and Evolution·L F Jacobs, W D Spencer
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·P R Rapp, M Gallagher
Feb 1, 1997·Current Opinion in Neurobiology·J E Lee
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P TanapatE Gould
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Dec 5, 1998·Biochemical and Biophysical Research Communications·N MatsuoK Okubo
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R Kornack, P Rakic
Dec 22, 1999·Biological Psychiatry·E Gould, P Tanapat
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz
Jun 5, 2001·Nature Reviews. Neuroscience·Y Feng, C A Walsh
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·E GouldC G Gross
Dec 26, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R S Nowakowski, N L Hayes
Mar 19, 2002·Journal of Neuroscience Methods·N KeeJ M Wojtowicz
Apr 12, 2002·Brain Research. Developmental Brain Research·N L Hayes, R S Nowakowski
Apr 12, 2002·Brain Research. Developmental Brain Research·Michelle F AndersonPeter S Eriksson
Apr 30, 2002·Brain, Behavior and Evolution·E FontJ M García-Verdugo
Apr 30, 2002·Brain, Behavior and Evolution·F Doetsch, C Scharff
Sep 3, 2002·Journal of Neuroscience Research·Philippe Taupin, Fred H Gage
Oct 23, 2002·Journal of Neuroscience Research·Galynn Zitnik, George M Martin
Dec 21, 2002·The European Journal of Neuroscience·Oliver von Bohlen und Halbach, Klaus Unsicker
Dec 21, 2002·Neurobiology of Aging·Jeanine I H KeukerEberhard Fuchs
Mar 18, 2003·The Journal of Comparative Neurology·David A MerrillMark H Tuszynski
Apr 30, 2003·The Journal of Comparative Neurology·Alexandre G DayerHeather A Cameron
Jun 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ming ZhaoAnn Marie Janson
Oct 24, 2003·The Journal of Comparative Neurology·Jason P BrownH Georg Kuhn

❮ Previous
Next ❯

Citations

Sep 6, 2007·Cell and Tissue Research·Marta Andres-MachJohn R Fike
Oct 30, 2008·Biology Letters·Irmgard Amrein, Hans-Peter Lipp
Sep 24, 2013·Journal of Neurosurgery. Pediatrics·Sabrina R TaylorAnn-Christine Duhaime
Jan 27, 2010·Biochimica Et Biophysica Acta·Cindy K Barha, Liisa A M Galea
Apr 18, 2009·Behavioural Brain Research·Gilles GheusiPierre-Marie Lledo
May 6, 2008·Neurobiology of Aging·Nada M-B Ben AbdallahHans-Peter Lipp
Feb 5, 2008·Neurobiology of Learning and Memory·Sudarshan S PatilGert Lubec
Nov 6, 2007·Neurobiology of Disease·Qian ChenYa-Ping Tang
Mar 26, 2016·Frontiers in Neuroanatomy·R Maarten van DijkIrmgard Amrein
Jan 16, 2007·Progress in Neurobiology·Benjamin W Lindsey, Vincent Tropepe
Dec 22, 2004·The European Journal of Neuroscience·Irmgard AmreinHans-Peter Lipp
Jan 14, 2009·Hippocampus·Jonathan Richard EppLiisa Ann Margaret Galea
Sep 21, 2011·The European Journal of Neuroscience·Anat Barnea, Vladimir Pravosudov
Sep 21, 2011·The European Journal of Neuroscience·Jennifer M BarkerJan Martin Wojtowicz
Jan 28, 2010·The European Journal of Neuroscience·M J García-FusterH Akil
Mar 15, 2013·Neuroscience·N PatzkeP R Manger
Jun 7, 2014·Frontiers in Neuroanatomy·Irmgard AmreinMaria K Oosthuizen
Sep 6, 2012·Nature Reviews. Neuroscience·Gerd Kempermann
Nov 18, 2018·Frontiers in Veterinary Science·Chiara La Rosa, Luca Bonfanti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.