Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

Proceedings of the National Academy of Sciences of the United States of America
Kenneth J RitchieC Roland Wolf

Abstract

Glutathione transferases are a multigene family of proteins that catalyze the conjugation of toxic electrophiles and carcinogens to glutathione. Glutathione transferase Pi (GSTP) is commonly overexpressed in human tumors and there is emerging evidence that the enzyme has additional cellular functions in addition to its role in drug and carcinogen detoxification. To investigate the unique functions of this enzyme, we have crossed Gstp null mice with an initiated model of colon cancer, the Apc(Min) mouse. In contrast to the Apc(Min/+) Gstp1/p2(+/+) (Gstp-wt Apc(Min)) mice, which rarely develop colonic tumours, Apc(Min/+)Gstp1/p2(-/-) (Gstp-null Apc(Min)) mice had a 6-fold increase in colon adenoma incidence, and a 50-fold increase in colorectal adenoma multiplicity, relative to Gstp-wt Apc(Min). This increase was associated with early tumor onset and decreased survival. Analysis of the biochemical changes in the colon tissue of Gstp-null Apc(Min) mice demonstrated a marked induction of many inflammatory genes, including IL-6, IL-4, IFN-gamma, and inducible nitric oxide synthase. In support of the induction of inducible nitric oxide synthase, a profound induction of nitrotyrosine adducts was observed. Gstp therefore appears to pla...Continue Reading

References

Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C J HendersonC R Wolf
Mar 4, 1999·The EMBO Journal·V AdlerZ Ronai
Jul 23, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·D L Eaton, T K Bammler
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·C J HendersonB K Park
May 4, 2002·Nature Cell Biology·Eitan Shaulian, Michael Karin
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kevin M HaigisWilliam F Dove
Jul 3, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gillian SmithC Roland Wolf
Nov 20, 2002·The Journal of Clinical Investigation·Feng HongBin Gao
Jul 29, 2003·Journal of Surgical Oncology·Yuan-Chang Chung, Ya-Fen Chang
Aug 20, 2003·The Journal of Clinical Investigation·Rachel M McLoughlinNicholas Topley
Feb 5, 2004·World Journal of Gastroenterology : WJG·Shao-Heng He
Jun 17, 2004·Genes & Development·Owen J SansomDouglas J Winton
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Chinthalapally V RaoWei Dai
Jun 24, 2005·Nature·Eduard BatlleHans Clevers
Mar 21, 2006·Biochemical Society Transactions·C L Bevins
Sep 26, 2007·International Journal of Cancer. Journal International Du Cancer·S Perwez Hussain, Curtis C Harris
Dec 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Elias GounarisKhashayarsha Khazaie
Sep 2, 2008·Cancer Research·S Perwez HussainCurtis C Harris
Sep 13, 2008·American Journal of Respiratory and Critical Care Medicine·Jiansheng ZhouDianne C Webb
Dec 17, 2008·Mucosal Immunology·S K LindenM A McGuckin
Feb 14, 2009·Journal of Gastroenterology and Hepatology·Malith RamasundaraAndrew S Day

❮ Previous
Next ❯

Citations

Mar 14, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhenlong WangZiming Wang
Oct 7, 2011·Cancer Research·Colin J HendersonC Roland Wolf
Mar 29, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin H KenslerPatricia A Egner
Mar 24, 2011·Drug Metabolism Reviews·Colin J Henderson, C Roland Wolf
Apr 28, 2010·Gastroenterology·Kory W JaspersonRandall W Burt
Jan 28, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mussarat WahidMahmood Akhtar Kayani
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Nosheen MasoodMahmood Akhtar Kayani
Dec 4, 2012·Biochimica Et Biophysica Acta·Philip G Board, Deepthi Menon
Mar 17, 2015·Current Pharmacology Reports·Savita SinghSanjay Gupta
Mar 7, 2012·Angewandte Chemie·Volker GatterdamRobert Tampé
Aug 28, 2015·The Journal of Pharmacology and Experimental Therapeutics·David J McGarryColin J Henderson
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Paul W TettehHans Clevers
Oct 15, 2020·Biomolecules·Luke KennedyMiroslava Cuperlovic-Culf
May 6, 2015·Cancer Immunology Research·Vonny I LeoPatrick T Reilly
Jun 18, 2014·Cancer Research·Colin J HendersonC Roland Wolf
Jul 1, 2018·Cancer Letters·Anupam Chatterjee, Sanjay Gupta
Oct 8, 2014·Disease Models & Mechanisms·Amy A IrvingJames M Amos-Landgraf
Sep 17, 2021·Communications Biology·Elena V KnatkoAlbena T Dinkova-Kostova
Dec 15, 2010·Biochimica Et Biophysica Acta·J HeijmansG R van den Brink
Sep 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shuwen YuLu Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.