PMID: 2108017Mar 1, 1990Paper

Markedly increased omega-oxidation of valproate in fulminant hepatic failure

Epilepsia
T KuharaN Sakura

Abstract

Using gas chromatography-mass spectrometry, we showed that the urinary metabolite profile of valproate (VPA) in a subject receiving VPA and phenobarbital (PB) who died of fulminant hepatic failure was quite different from those of reported patients with Reye's syndrome or fatal hepatic failure. Only 2-n-propylglutarate, the end product of omega-oxidation of VPA, was excreted in markedly increased amounts, while other VPA metabolites were undetectable. Although the primary cause of fulminant hepatitis and the mechanism of enhanced VPA metabolism by the hepatic P-450 system in this patient are not clear, our findings suggest that P-450-mediated reactions become the predominant metabolic pathway of VPA in a stage of fulminant hepatic failure.

References

Jan 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KuharaN Sakura
Jan 1, 1982·Brain & Development·J SatohY Fukuyama
Apr 1, 1983·Journal of Clinical Pharmacology·E KingsleyR Tweedale
Oct 1, 1983·European Journal of Pediatrics·W KochenA Ritz
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J W KestersonJ M Machinist
Sep 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H J Zimmerman, K G Ishak
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J H LewisE Rosenberg
Nov 1, 1982·European Journal of Pediatrics·H BöhlesH Schäfer

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Citations

Jun 19, 1992·Pharmaceutisch Weekblad. Scientific Edition·F Pisani
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Abhishek Katiyar, Cynthia Aaron
Apr 30, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·T KuharaS Kuwabara
Oct 1, 1996·Epilepsy Research·T SugimotoK Murakami
Dec 6, 2006·Drug Metabolism Reviews·Thomas K H Chang, Frank S Abbott
Dec 12, 2002·Journal of Toxicology. Clinical Toxicology·Matthew D Sztajnkrycer
Aug 7, 2002·The Journal of Pharmacy and Pharmacology·U KreherF Wien
Jan 1, 1991·Journal of Child Neurology·L J WillmoreJ M Pellock
May 6, 2011·Clinical Pharmacology and Therapeutics·K E PriceJ S Leeder
May 1, 1993·The Annals of Pharmacotherapy·J DuarteL E Clavería

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