PMID: 7524151Jun 1, 1994Paper

Marker antibodies of rheumatoid arthritis: diagnostic and pathogenetic implications

Seminars in Arthritis and Rheumatism
K AhoP Kurki

Abstract

Rheumatoid arthritis (RA) is associated with several autoantibodies specific enough to serve as diagnostic and prognostic markers. These include rheumatoid factor (RF), antikeratin antibody (AKA), antiperinuclear factor (APF), and anti-RA33. The first three, and possibly also anti-RA33, may precede the onset of clinical RA. The prevalence of positive test reactions depends on the period between taking the specimen and onset of disease; when the period is short, the prevalence is nearly the same as in established disease. Thus, RA has a long asymptomatic period with broadening immunological activity. The assays for AKA and APF (and possibly also for anti-RA33), compared with RF testing, yielded greater specificity rather than the ability to define any subgroup with particularly severe disease. Used together, the above marker antibodies may form a new and more enlightened basis for defining seropositive RA. It is commonly believed that genetically mediated immune response plays an important role in the initiation of RA. However, the role of the major histocompatibility complex antigens may be in modulation of the inflammatory reaction in a later phase.

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Citations

Oct 31, 1998·Immunological Reviews·G Sønderstrup, H McDevitt
Jun 1, 1997·Annals of the Rheumatic Diseases·K AhoT Palosuo
Jul 27, 2000·Annals of the Rheumatic Diseases·M HeliövaaraA Aromaa
Dec 15, 2000·Annals of the Rheumatic Diseases·L PaimelaR von Essen
Apr 6, 2006·The Journal of Clinical Investigation·Kristine A KuhnV Michael Holers
Jul 24, 2012·Rheumatic Diseases Clinics of North America·Elizabeth W Karlson, Kevin Deane
Oct 15, 2003·Arthritis and Rheumatism·Darcy S Majka, V Michael Holers
Jul 29, 2006·Arthritis and Rheumatism·Margarita Rodríguez-MahouEduardo Fernández-Cruz
Oct 14, 2008·Expert Opinion on Biological Therapy·Theodorus van den BroekSalvatore Albani
Aug 13, 2005·Scandinavian Journal of Rheumatology·S Rantapää-Dahlqvist
Jan 1, 1995·Scandinavian Journal of Rheumatology·A MalmivaaraK Kurppa
Oct 1, 1996·Seminars in Arthritis and Rheumatism·J M BerthelotA Prost
May 8, 1998·Seminars in Arthritis and Rheumatism·K AhoT Klaukka
Jan 4, 2001·Journal of Clinical Laboratory Analysis·R M Nakamura
Jun 1, 1997·Critical Reviews in Clinical Laboratory Sciences·L M Hang, R M Nakamura
Apr 21, 2007·Rheumatology International·Rim SghiriIbtissem Ghedira
Aug 25, 2009·Clinical Rheumatology·Pirjo JuuselaSari Kiuru-Enari
Jul 15, 2005·Annals of the New York Academy of Sciences·I AbreuJ A Machado Caetano
Nov 11, 2011·Journal of Clinical Immunology·Mohamed ElrefaeiJohn L Schmitz
Jan 11, 2014·Current Osteoporosis Reports·Ulrike HarreGeorg Schett

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