Marker-assisted selection efficiency in populations of finite size.

Genetics
L MoreauA Gallais

Abstract

The efficiency of marker-assisted selection (MAS) based on an index incorporating both phenotypic and molecular information is evaluated with an analytical approach that takes into account the size of the experiment. We consider the case of a population derived from a cross between two homozygous lines, which is commonly used in plant breeding, and we study the relative efficiency of MAS compared with selection based only on phenotype in the first cycle of selection. It is shown that the selection of the markers included in the index leads to an overestimation of the effects associated with these markers. Taking this bias into account, we study the influence of several parameters, including experiment size and heritability, on MAS efficiency. Even if MAS appears to be most interesting for low heritabilities, we point out the existence of an optimal heritability (approximately 0.2) below which the low power of quantitative trait loci detection and the bias caused by the selection of markers reduce the efficiency. In this situation, increasing the power of detection by using a higher probability of type I error can improve MAS efficiency. This approach, validated by simulations, gives results that are generally consistent with th...Continue Reading

References

Oct 1, 1994·Genetical Research·A Gimelfarb, R Lande
Apr 1, 1994·Genetics·Z B Zeng
Feb 1, 1994·Genetical Research·A Gimelfarb, R Lande
Dec 1, 1995·Genetical Research·J C WhittakerR Thompson
Dec 1, 1996·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A Charcosset, A Gallais
Aug 1, 1995·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A Gimelfarb, R Lande
Jun 1, 1994·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·M D Edwards, N J Page
May 1, 1993·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W Zhang, C Smith
Apr 1, 1992·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·W Zhang, C Smith
Jan 1, 1976·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·M SollerA Genizi

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Citations

Aug 13, 2008·Genetica·Frédéric Hospital
Feb 2, 2002·Nature Reviews. Genetics·Jack C M Dekkers, Frédéric Hospital
Oct 1, 2003·Journal of Biosciences·P Narain
Feb 3, 2006·Yi chuan xue bao = Acta genetica Sinica·Peng-Yuan LiuLu Yan
Dec 14, 2006·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A GallaisA Charcosset
Sep 30, 2004·Genetics·Bertrand ServinFrédéric Hospital
Oct 14, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Z MicicA E Melchinger
Mar 27, 2007·Theoretical Population Biology·Xin-Sheng Hu
Aug 4, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·N PiyasatianJ C M Dekkers
Aug 21, 2015·G3 : Genes - Genomes - Genetics·J Jesus Ceron-RojasIan DeLacy
Mar 12, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A ThabuisA Palloix
Apr 8, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Pengyuan LiuYan Lu
Jul 31, 2009·Science in China. Series C, Life Sciences·XinHai Li, XueMei Deng
Jan 12, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Laurence PaulyPhilippe Barre

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