PMID: 11914137Mar 27, 2002Paper

Markers for early detection of cancer: statistical guidelines for nested case-control studies

BMC Medical Research Methodology
Stuart G BakerSudhir Srivastava

Abstract

Recently many long-term prospective studies have involved serial collection and storage of blood or tissue specimens. This has spurred nested case-control studies that involve testing some specimens for various markers that might predict cancer. Until now there has been little guidance in statistical design and analysis of these studies. To develop statistical guidelines, we considered the purpose, the types of biases, and the opportunities for extracting additional information. The following guidelines: (1) For the clearest interpretation, statistics should be based on false and true positive rates - not odds ratios or relative risks (2) To avoid overdiagnosis bias, cases should be diagnosed as a result of symptoms rather than on screening. (3) To minimize selection bias, the spectrum of control conditions should be the same in study and target screening populations. (4) To extract additional information, criteria for a positive test should be based on combinations of individual markers and changes in marker levels over time. (5) To avoid overfitting, the criteria for a positive marker combination developed in a training sample should be evaluated in a random test sample from the same study and, if possible, a validation sampl...Continue Reading

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Citations

Jul 4, 2009·Journal of the National Cancer Institute·Stuart G Baker
Jun 6, 2012·Prostate Cancer·Kristina A TrujilloMarco Bisoffi
Dec 1, 2009·Biometrika·Ying Huang, Margaret Sullivan Pepe
Oct 9, 2008·Journal of the National Cancer Institute·Margaret S PepeJohn D Potter
Dec 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David F Ransohoff, Margaret L Gourlay
Nov 14, 2014·Cancer Informatics·Nancy Lan Guo, Ying-Wooi Wan
Jul 19, 2016·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·Stefan Weiser
Sep 20, 2002·BMC Medical Research Methodology·Stuart G BakerPhilip C Prorok
Feb 19, 2004·Journal of the National Cancer Institute·Renske D M SteenbergenPeter J F Snijders
Dec 31, 2009·Clinical Chemistry·David F Ransohoff
Jul 15, 2005·Current Opinion in Critical Care·Nicola LatronicoElisa Seghelini
Jun 9, 2010·Statistics in Medicine·Ying Huang, Margaret Sullivan Pepe
Sep 25, 2012·European Journal of Clinical Investigation·Andrew RundlePaolo Vineis
Sep 22, 2015·Journal of the National Cancer Institute·Stuart G Baker
Apr 2, 2016·Statistical Analysis and Data Mining·Jean-Eudes DazardJ Sunil Rao
Oct 11, 2017·Statistics in Biosciences·Debashis Ghosh
Mar 17, 2006·Clinical Trials : Journal of the Society for Clinical Trials·Stuart G BakerSteven Skates
May 16, 2008·Expert Opinion on Therapeutic Targets·Liu Hong, Daiming Fan
Apr 2, 2004·Nature Reviews. Cancer·David F Ransohoff
Sep 25, 2008·Journal of the National Cancer Institute·Hong-Seok ParkBogdan Czerniak
Jan 1, 2010·Journal of the Royal Statistical Society. Series C, Applied Statistics·Y Huang, M S Pepe
Jun 13, 2012·Cancer Prevention Research·Mohamed HassaneinPierre P Massion
Feb 2, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kunitoshi ShigeyasuAjay Goel
Sep 11, 2012·Cancer Research·Georgios NikolaidisTriantafillos Liloglou
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin W McIntoshEleftherios P Diamandis
Jul 10, 2012·Gastroenterology·Elizabeth L Bird-LiebermanRebecca C Fitzgerald
Sep 22, 2021·Journal of Biopharmaceutical Statistics·Yougui Wu

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