Abstract
There is growing interest and concern in society about the capacity of chemicals to impair immune responses and trigger autoimmune disease. Methods to investigate chemical-induced immunosuppression have been developed and validated in the mouse and rat. Animal models that are suitable to investigate the ability of chemicals to induce autoimmune disease are virtually lacking. From the plethora of tests to assess immunity in man, panels of biomarkers to study immunotoxicity in humans have been proposed. Such studies in humans are considerably more complex than in animals as non-invasive tests are limited, responses in the population are heterogeneous, and exposure levels are often low. Human risk assessment is therefore mostly based on animal studies. As examples of compounds affecting biomarkers in animals and man, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hexachlorobenzene are discussed.
References
Jan 1, 1991·Toxicology·M P HolsappleD L Morris
Sep 15, 1989·Toxicology and Applied Pharmacology·B van OmmenP J van Bladeren
Jun 1, 1989·Brain, Behavior, and Immunity·S ZalcmanH Anisman
Sep 26, 1986·Cell·W SchulerM J Bosma
Jan 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterJ H Dean
Jan 1, 1983·International Journal of Immunopharmacology·K J Stelzer, T L Pazdernik
Oct 1, 1984·The British Journal of Dermatology·D J CrippsI Dogramici
Oct 1, 1981·Toxicology and Applied Pharmacology·K J ChangT C Tung
Feb 1, 1982·Journal of Toxicology and Environmental Health·K J ChangT P Lee
Jun 26, 1995·Toxicology·C de HeerH van Loveren
Jan 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M K SelgradeM I Luster
Jan 1, 1995·Human & Experimental Toxicology·H Van Loveren
Jan 1, 1995·Human & Experimental Toxicology·H B Koëter
May 24, 1993·Toxicology·A M Cummings
Citations
Nov 26, 2003·International Immunopharmacology·Sadia AyubNibhriti Das
Jun 1, 1997·Chemosphere·P LangerE Hanzen
Jan 4, 2001·Toxicology Letters·P MoszczyńskiZ Tabarowski
Jun 8, 2002·Toxicology Letters·Michael P Holsapple
Jul 27, 2002·Domestic Animal Endocrinology·F GandolfiB Fischer
Dec 14, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Guillermo A Blanco, Edwin L Cooper
Oct 4, 2012·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Julieta Castillo-CadenaEduardo Madrigal-Bujaidar
Jan 24, 2014·Journal of Toxicology·Dorothy M TappendenJohn J Lapres
Sep 28, 2004·Basic & Clinical Pharmacology & Toxicology·Naser Z Alsharif, Ezdihar A Hassoun
Jan 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ching-Yun KuoMing-Ju Chen
Feb 26, 2016·Journal of Toxicology and Environmental Health. Part a·Michelle M AngrishDavid W Herr
Oct 20, 1998·Arthritis and Rheumatism·G S CooperG S Gilkeson
May 20, 1998·Human & Experimental Toxicology·M L QueirozC A Souza
Apr 13, 2011·Inflammatory Bowel Diseases·Conor LahiffAlan C Moss