Markers for immunotoxic effects in rodents and man

Toxicology Letters
J G Vos, H Van Loveren

Abstract

There is growing interest and concern in society about the capacity of chemicals to impair immune responses and trigger autoimmune disease. Methods to investigate chemical-induced immunosuppression have been developed and validated in the mouse and rat. Animal models that are suitable to investigate the ability of chemicals to induce autoimmune disease are virtually lacking. From the plethora of tests to assess immunity in man, panels of biomarkers to study immunotoxicity in humans have been proposed. Such studies in humans are considerably more complex than in animals as non-invasive tests are limited, responses in the population are heterogeneous, and exposure levels are often low. Human risk assessment is therefore mostly based on animal studies. As examples of compounds affecting biomarkers in animals and man, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and hexachlorobenzene are discussed.

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Citations

Jan 4, 2001·Toxicology Letters·P MoszczyńskiZ Tabarowski
Jun 8, 2002·Toxicology Letters·Michael P Holsapple
Jul 27, 2002·Domestic Animal Endocrinology·F GandolfiB Fischer
Dec 14, 2004·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Guillermo A Blanco, Edwin L Cooper
Oct 4, 2012·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Julieta Castillo-CadenaEduardo Madrigal-Bujaidar
Jan 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ching-Yun KuoMing-Ju Chen
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May 20, 1998·Human & Experimental Toxicology·M L QueirozC A Souza
Apr 13, 2011·Inflammatory Bowel Diseases·Conor LahiffAlan C Moss

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