Markers for predicting severity and progression of acute pancreatitis

Best Practice & Research. Clinical Gastroenterology
Kerstin Schütte, Peter Malfertheiner

Abstract

Several tools have been developed for severity stratification in acute pancreatitis. They include single biochemical markers, imaging methods, and complex scoring systems, all of which aim at an early detection of severe acute pancreatitis to optimise monitoring and treatment of patients as early as possible. Among single biochemical markers, C-reactive protein (CRP) remains the most useful. Despite its delayed increase, peaking not earlier than 72 h after the onset of symptoms, it is accurate and widely available. Many other markers have been evaluated for their usefulness, and for some of them very promising data could be shown. Among them interleukin 6 seems to be the most promising parameter for use in clinical routine. For the detection of pancreatic infection, procalcitonin is the most sensitive, and can be used as an indicator for the need for fine-needle aspiration of pancreatic necrosis. Regarding imaging, contrast-enhanced computed tomography is still the reference method for the detection of necrotising acute pancreatitis. Pancreatitis-specific scoring systems have been shown to be of value for the prediction of severity and progression of acute pancreatitis, but cannot be applied any earlier than 48 h after admissio...Continue Reading

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References

Feb 1, 1990·Radiology·E J BalthazarJ H Ranson
Oct 1, 1986·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·M BüchlerH G Beger
Oct 1, 1985·Digestive Diseases and Sciences·I G RennerV J Renner
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Dec 1, 1984·Gut·S L BlameyD C Carter
Jan 1, 1980·The British Journal of Surgery·M J McMahonI R Pickford
Nov 1, 1994·The British Journal of Surgery·C Armbruster, S Kriwanek
Nov 1, 1994·Radiology·E J BalthazarE vanSonnenberg
Jun 1, 1994·The British Journal of Surgery·D V MannG Glazer
Feb 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·G TalaminiG Cavallini
Feb 1, 1997·World Journal of Surgery·H G BegerU Pralle
Apr 1, 1997·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S TennerP A Banks
Jul 1, 1997·Digestive Diseases and Sciences·R PezzilliB Barakat
Sep 1, 1997·Gastroenterology·S TennerP A Banks
Nov 20, 1998·The American Journal of Gastroenterology·J D BaillargeonP A Banks
Jun 11, 1999·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·R PezzilliF Miglio
Oct 30, 1999·The British Journal of Surgery·C J McKayC W Imrie
Jul 27, 2001·The American Journal of Gastroenterology·P G LankischA B Lowenfels
Jan 10, 2002·Journal of Clinical Gastroenterology·Stuart L Triester, Kris V Kowdley
Jun 20, 2002·Critical Care Medicine·Kimmo I HalonenReijo K Haapiainen
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·T BlumP G Lankisch
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·C J McKay, A Buter
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jens WernerMarkus W Büchler

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Citations

Aug 13, 2011·Antioxidants & Redox Signaling·Thilo Hackert, Jens Werner
Jun 24, 2010·Hybridoma·Huimin DongYingsong Wu
Feb 18, 2009·Journal of Gastroenterology and Hepatology·Ping XueQing Xia
Jul 28, 2010·Journal of Gastroenterology and Hepatology·Xin WangNaiqiang Cui
Jun 2, 2012·World Journal of Gastroenterology : WJG·Hai-Hang Zhu, Lin-Lin Jiang
Oct 15, 2013·World Journal of Gastroenterology : WJG·Makoto OtsukiYoshifumi Takeyama
Feb 28, 2014·Seminars in Immunology·Marina LesinaHana Algül
Apr 2, 2014·Cirugía española·Ramón VilallongaJoaquim Balsells
Sep 20, 2015·International Journal of Surgery·Maryam NesvaderaniMichael R Cox
Sep 27, 2008·Acta otorrinolaringológica española·María Paz CuestaCarlos Suárez
Jun 8, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bechien U WuDarwin L Conwell
Jul 15, 2015·Critical Reviews in Clinical Laboratory Sciences·Sebastian Manuel StaubliChristian Andreas Nebiker
Jul 14, 2010·Journal of Clinical Periodontology·Emma MegsonP Mark Bartold
Jul 9, 2009·Journal of Zhejiang University. Science. B·Xi-Ping ZhangJie Zhang
Sep 13, 2014·Gastroenterology Research and Practice·Markus NistalAndrea Pace
Apr 9, 2015·Critical Care : the Official Journal of the Critical Care Forum·Yun-Shing PengMing-Hung Tsai
Oct 14, 2016·Free Radical Research·Fabíula Francisca AbreuEnilton Aparecido Camargo
Nov 6, 2015·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Alexandre de Figueiredo FerreiraIure Kalinine Ferraz de Souza
Dec 1, 2017·Archivum Immunologiae Et Therapiae Experimentalis·Pascaline FontehMartin Brand
Dec 2, 2017·ANZ Journal of Surgery·Tishanthan PathmarajahDieter G Weber
Jan 20, 2011·The American Journal of Gastroenterology·Andreas SchäfflerTanja Brünnler
Feb 1, 2019·Scandinavian Journal of Gastroenterology·Berglind A MagnusdottirEinar S Björnsson
Apr 7, 2010·Scandinavian Journal of Gastroenterology·Zilvinas DambrauskasGiedrius Barauskas
Apr 30, 2009·Anaesthesia and Intensive Care·K M Ho, J Lipman
Mar 16, 2013·European Journal of Gastroenterology & Hepatology·Filipe S CardosoJoão R Deus
Feb 9, 2021·Annals of Internal Medicine·Timothy B Gardner
Feb 25, 2019·The American Journal of the Medical Sciences·Ziqiang ZhaoJiaqing Shen

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