PMID: 2492586Jan 1, 1989Paper

Markers for progression to acquired immune deficiency syndrome and zidovudine treatment of asymptomatic patients

The Journal of Infection
J M LangeJ Goudsmit

Abstract

Eighteen asymptomatic men with persistent human immunodeficiency virus type I (HIV-I) p24 antigenaemia were treated with zidovudine 250-500 mg (+/- acyclovir 800 mg) 6-hourly for 4-12 weeks, and subsequently with zidovudine 500 mg (+/- acyclovir 1600 mg) 12-hourly for 36 weeks. After 24 weeks six additional HIV antigenaemic subjects were entered and treated directly with zidovudine 500 mg 12-hourly. Over the treatment period serum HIV-I p24 (HIV-Ag) levels declined in all 24 subjects; significantly so in 17, and to below cut-off values in five. Mean serum HIV-Ag levels in different treatment groups declined in 68-78%. Initial increases in CD4+ cell counts were not sustained. Over 48 weeks serum HIV-Ag levels rose in three out of five non-treated men with persistent HIV antigenaemia, and they slightly declined in two; the mean serum HIV-Ag level in this group rose 67%. Regression of enlarged lymph nodes was seen in 19 out of 19 of the zidovudine-treated subjects. In the 24 zidovudine-treated subjects no disease progression occurred during follow-up, whereas two out of five non-treated men went on to develop CDC group IV A, and IV C-2 disease, respectively. Adverse reactions to the study drugs were infrequent and mild. Anaemia ca...Continue Reading

References

Oct 1, 1986·The Journal of Infectious Diseases·J M TaylorR Detels
Apr 4, 1987·British Medical Journal·C A CarneM W Adler
Sep 5, 1987·British Medical Journal·F de WolfJ van der Noordaa
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Dec 12, 1985·The New England Journal of Medicine·U Mathur-WaghR T Senie

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