Markers of airway inflammation in primary ciliary dyskinesia studied using exhaled breath condensate

Pediatric Pulmonology
Nadwa ZihlifAndrew Bush

Abstract

Macroscopically, the airways in primary ciliary dyskinesia (PCD) are inflamed and infected, and the eventual result is bronchiectasis. The measurement of noninvasive markers of inflammation in PCD may allow determination of mechanisms of tissue damage, and even allow monitoring of therapy. The aim of this study was to measure in exhaled breath condensate (EBC) of children with PCD the concentrations of the neutrophil chemoattractants leukotriene (LT) B4 and interleukin (IL)-8 and the marker of oxidative stress 8-isoprostane (8-IP), and to try determining whether these markers can be used to assess mechanisms of airway inflammation in these patients. Concentrations of LTB4, IL-8, and 8-IP in the EBC of 23 PCD and 11 age-matched healthy children were measured using an enzyme immunoassay (EIA). The children also performed spirometry and underwent sputum induction, the latter for differential cell count. The concentrations of 8-IP in EBC of children with stable PCD were significantly increased compared to normal controls (median, 7.8 pg/ml vs. 3.1 pg/ml; P = 0.004). There was no difference in the median concentrations of EBC LTB4 between PCD subjects and healthy controls (28 pg/ml vs. 28 pg/ml; P = 0.5). IL-8 levels were below the ...Continue Reading

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Citations

Jul 14, 2010·Respiratory Research·Chiara PorroAngela B Maffione
Oct 13, 2010·Pediatric Research·Greg D WellsAllan L Coates
Jul 3, 2013·American Journal of Respiratory and Critical Care Medicine·Samantha J IrvingAndrew Bush
Nov 15, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E van MastrigtM W Pijnenburg
Jul 10, 2007·Respiratory Medicine·Neeta KulkarniJonathan Grigg
Mar 9, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Henrik Ryberg, Kenneth Caidahl
Mar 1, 2018·European Journal of Pediatrics·Senem SimsekHulya Arikan
Apr 10, 2018·BMC Proceedings·Florian HalbeisenJane S Lucas
Feb 22, 2014·Physiological Measurement·B VogtI Frerichs
Sep 1, 2008·Journal of Breath Research·Silvia Carraro, Eugenio Baraldi
May 22, 2019·ERJ Open Research·Florian S HalbeisenMyrofora Goutaki
Aug 28, 2020·Pediatric Investigation·Xiang ZhangShunying Zhao
May 21, 2019·Human Molecular Genetics·Agnes CheongJesse Mager
Sep 19, 2020·Nature Reviews. Disease Primers·Julia WallmeierHeymut Omran
Apr 4, 2021·Journal of Clinical Medicine·María MagallónFrancisco Dasí

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