Markers of angiogenesis and macrophage products for predicting disease course and monitoring vascular inflammation in giant cell arteritis

Rheumatology
Yannick van SleenElisabeth Brouwer

Abstract

GCA, a systemic vasculitis, is characterized by an IL-6-dependent acute-phase response. This response is typically suppressed by treatment rendering CRP/ESR unreliable for monitoring vascular inflammation. Also, there are no accurate biomarkers predicting a non-favourable disease course. Here we investigated macrophage products and markers of angiogenesis as biomarkers for prognosis and monitoring of vascular inflammation. Forty-one newly diagnosed, glucocorticoid-naive GCA patients were prospectively followed for relapses and glucocorticoid requirement for a median of 30 months (range 0-71). Serum markers at baseline and during follow-up were compared with 33 age-matched healthy controls and 13 infection controls. Concentrations of IL-6, serum amyloid A, soluble CD163, calprotectin, YKL-40, VEGF, angiopoietin-1 and -2 and sTie2 were determined by ELISA/Luminex assay. Serum concentrations of all markers, but not angiopoietin-1, were elevated in GCA patients at baseline when compared with healthy controls. High VEGF (P = 0.0025) and angiopoietin-1 (P = 0.0174) and low YKL-40 (P = 0.0369) levels at baseline were predictive of a short time to glucocorticoid-free remission. Elevated angiopoietin-2 levels were associated with an imm...Continue Reading

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Citations

May 21, 2020·Zeitschrift für Rheumatologie·E Wipfler-FreißmuthM Both
Aug 8, 2020·Nature Reviews. Rheumatology·Dario CamellinoChristian Dejaco
Sep 12, 2019·Frontiers in Immunology·Yannick van SleenElisabeth Brouwer
Feb 12, 2021·Current Rheumatology Reports·Enrico TombettiDario Camellino
Mar 9, 2021·Frontiers in Immunology·Iva Sorić HosmanLovro Lamot
Mar 16, 2021·Frontiers in Immunology·Mitsuhiro AkiyamaCornelia M Weyand
May 6, 2021·Free Radical Biology & Medicine·Nan YangMing-Lin Liu
May 18, 2021·BioMed Research International·Xiayire AierkenNanfang Li

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Methods Mentioned

BETA
ESR
biopsy
ELISA
dissection
biopsies

Software Mentioned

SPSS
GraphPad Prism

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