Abstract
Apoptosis is a highly conserved energy-requiring program for non-inflammatory cell death that is important in both normal physiology and disease. Numerous techniques have been used to study apoptosis. In the nervous system, apoptosis is necessary for normal development, but it also occurs in many acute and chronic pathologic conditions. This review places commonly used markers of apoptosis and their detection in the context of what is now known about the process of apoptosis. We review the potential role of apoptosis in nervous system and neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis). We then describe important morphological, immunocytochemical, and molecular genetic markers for apoptosis, including proteases, signal transduction molecules, and mitochondrial proteins. The possibility of manipulating apoptosis therapeutically in conditions of too many or too few cells is under active investigation.
Citations
Mar 2, 2005·Irish Journal of Medical Science·E F Gaffney
Jan 20, 2018·Scientific Reports·Evelyn Chukwurah, Rekha C Patel
Jan 27, 2019·Food Science & Nutrition·You-Suk LeeHae-Jeung Lee
Jan 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ju Yeon ChoiJong Oh Kim
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Arlene R Collins
Jul 5, 2007·Apoptosis : an International Journal on Programmed Cell Death·Wei-Li WangWey-Jinq Lin
Jan 18, 2006·Journal of Neuropathology and Experimental Neurology·Lynette G SheffieldSuzanne S Mirra
Dec 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Jae Chan ParkSae Kwang Ku
Aug 16, 2006·Neuro-degenerative Diseases·Gilles J GuilleminBruce J Brew
Oct 7, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kasie Cole, J Regino Perez-Polo
Aug 13, 2011·Lab on a Chip·Rafał WalczakAnna Chełmońska Soyta
Dec 21, 2013·Scientific Reports·Dayanjali WijesingheOleg A Andreev
May 6, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ji Yun JungSang Chan Kim
Jun 8, 2017·Experimental and Therapeutic Medicine·Choong-Gon KimSae-Kwang Ku
Mar 7, 2003·American Journal of Physiology. Renal Physiology·Babu J Padanilam
Dec 16, 2003·Cell Biology Education·Susan M DiBartolomeis, James P Moné
Aug 18, 2020·Human Molecular Genetics·Alexey V ShevelkinMikhail V Pletnikov
May 21, 2021·International Journal of Nanomedicine·Guo YuFakhar Ud Din
Jun 27, 2021·The International Journal of Biochemistry & Cell Biology·Benedicth UkhueduanRekha C Patel
Jul 9, 2021·Apoptosis : an International Journal on Programmed Cell Death·Xiaofeng DaiJianying Zhang