Markers of bacteremia in febrile neutropenic patients with hematological malignancies: procalcitonin and IL-6 are more reliable than C-reactive protein

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M von Lilienfeld-ToalF Stuber

Abstract

Since neutropenic patients with hematological malignancies are at high risk of contracting life-threatening infections, specific markers of infection are needed in cases of febrile neutropenia. The study presented here assessed serum concentrations of C-reactive protein (CRP), procalcitonin (PCT) and interleukin-6 (IL-6) in samples obtained from 31 febrile neutropenic patients. A total of 53 episodes were evaluated, and 18 of these were associated with positive blood culture results. Procalcitonin and IL-6 concentrations differed significantly between bacteremic and non-bacteremic episodes. Procalcitonin values were 0.22 ng/ml [interquartile range (IR), 0.15-1.9] for patients with pneumonia without bacteremia, 0.22 ng/ml (IR, 0.16-0.55) for patients with fever of unknown origin, 0.2 ng/ml (IR, 0.13-0.57) for patients with non-microbial fever and 1.8 ng/ml (IR, 0.35-5.3) for patients with bacteremia. The differences between bacteremic and non-bacteremic episodes had a P-value of 0.003 using the Mann-Whitney test. For IL-6 the median values were 301 pg/ml (IR, 152-1,879) for patients with pneumonia without bacteremia, 207 pg/ml (IR, 94-445) for patients with fever of unknown origin, 177 pg/ml (IR, 142-208) for patients with non-m...Continue Reading

Citations

Oct 7, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Maria HatzistilianouDorothea Catriu
Feb 23, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G N MatwiyoffM Daheshia
Aug 10, 2006·Intensive Care Medicine·Pierre Emmanuel CharlesBernard Blettery
Jun 13, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L KitanovskiM Derganc
Aug 8, 2008·Medical Oncology·Nuray BuyukberberCelalettin Camci
Jan 20, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Winfried V Kern
Jul 14, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Silke SchuttrumpfClaudia Binder
May 21, 2011·Critical Care : the Official Journal of the Critical Care Forum·Pedro PóvoaJorgeI F Salluh
Jun 30, 2007·Critical Care : the Official Journal of the Critical Care Forum·Michal KyrJaroslav Michalek
May 31, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M von Lilienfeld-ToalF Stüber
Jan 28, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yan-Qiang HouSunghee Kim
Nov 26, 2013·Enfermedades infecciosas y microbiología clínica·Marina Sánchez-YepesBlanca Ortiz-Muñoz
May 17, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G MaschmeyerUNKNOWN Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology
Oct 8, 2008·Annals of the New York Academy of Sciences·Michael Ellis
Feb 23, 2011·International Journal of Laboratory Hematology·D-H ParkK Han
Nov 15, 2011·Pediatric Blood & Cancer·Yongmin TangShilong Yang
Dec 28, 2005·The American Journal of Medicine·Yasuharu TokudaTomokazu Kishaba
Dec 6, 2006·La Revue de médecine interne·P Hausfater
Sep 20, 2011·Human Immunology·Tomasz MikułaAlicja Wiercińska-Drapało
Apr 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shigeo FujiYoichi Takaue
Nov 24, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·R P H PetersA B J Groeneveld
Apr 6, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y TangB Pan
Jun 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ugur SahinTaner Demirer
Oct 26, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T XiaY Tang
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
May 17, 2007·São Paulo Medical Journal = Revista Paulista De Medicina·José Eduardo de Aguilar-NascimentoCor Jesus Fernandes Fontes
Nov 30, 2005·Electrophoresis·Tom G HoltSusan P Rohrer
Aug 24, 2006·British Journal of Haematology·Julia C Chisholm, Rachel Dommett
May 1, 2019·The Cochrane Database of Systematic Reviews·Daniel Molano FrancoJavier Zamora
Jan 5, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Munirah Al ShuaibiIssam Raad

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