Markers of Borna disease virus infection in cats with staggering disease

Journal of Feline Medicine and Surgery
Jonas Johansson WensmanBodil S Holst

Abstract

Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.

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Citations

Jun 1, 2006·The Veterinary Quarterly·S Kamhieh, R L P Flower
Nov 5, 2013·Acta Veterinaria Scandinavica·Sigríður BjörnsdóttirJonas Johansson Wensman
Feb 1, 2014·The Veterinary Journal·Jonas Johansson WensmanMikael Berg
May 24, 2016·Animal Health Research Reviews·Ian TizardSusan Payne
Oct 11, 2016·PloS One·Frank VandenbusscheSteven Van Borm
Jun 24, 2015·Journal of Feline Medicine and Surgery·Hans LutzUNKNOWN European Advisory Board on Cat Diseases
Jan 1, 2012·Uirusu·Keizo Tomonaga
Nov 20, 2019·Infection Ecology & Epidemiology·Marlene Cavaleiro PintoGertrude Thompson

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Methods Mentioned

BETA
PCR

Software Mentioned

Rotor
Gene Real - Time Analysis Software

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