PMID: 9565813May 5, 1998Paper

Markers of cellular dysoxia during orthotopic liver transplantation in pigs

Intensive Care Medicine
A de JaegerM Lambert

Abstract

To characterize global, regional, and end-organ markers of cellular dysoxia during orthotopic liver transplantation and early reperfusion in pigs. Descriptive study. University hospital research laboratory. 7 fasted, anesthetized, and mechanically ventilated Yorkshire pigs underwent orthotopic liver transplantation. Oxygen consumption (VO2) and oxygen delivery (DO2) were both calculated using standard formulae. Gastric interstitial pH and the gastroarterial partial pressure of carbon dioxide (PCO2) gradient were measured with a gastric tonometer. The following were determined from arterial blood samples: serum lactate to pyruvate ratio, serum 3-hydroxybutyrate to acetoacetate ratio, plasma free fatty acids, and plasma free and total carnitine levels. Data were collected 1 h after induction of anesthesia (I), at the end of the anhepatic phase (A), and 1 h after reperfusion (R), Median (range) VO2 values obtained at the specified time points were: I 318 (206-1860), A 210 (152-408), R 330 (214-424) ml/kg per min, respectively (NS); DO2 values were: I 1828 (1382-3259), A 1219 (452-2492), R 1741 (1345-12,071) ml/kg per min, respectively (NS). The lactate to pyruvate ratio, reflecting the redox potential of the cytosol, progressively...Continue Reading

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Citations

Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Feb 3, 2005·Transplantation Proceedings·K K TsinariA G Tzakis
Jun 1, 2017·Biochemical and Biophysical Research Communications·Gianluca PaventiSalvatore Passarella

Related Concepts

Acetoacetic acid, sodium salt
Acetoacetates
Metazoa
Bicarnesine
Cytoplasmic Matrix
Nonesterified Fatty Acids
Hydroxybutyric Acids
Oxidation-Reduction
Oxygen Consumption
Receiver Operating Characteristic

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