Markers of cognitive decline in PD: The case for heterogeneity

Parkinsonism & Related Disorders
Oury MonchiPierre Bellec

Abstract

Cognitive impairment is highly prevalent and has a severe negative effect on health related and perceived quality of life in Parkinson's disease (PD). It is now established that 20-40% of persons with PD will develop cognitive deficits early in the disease. Moreover, the risk of developing dementia is six times higher in PD patients than in age-matched controls and it is estimated that 80% of patients will develop dementia after 20 years of the disease. In order to address these symptoms properly it is crucial to identify very early in the disease the patients who are most likely to develop dementia rapidly. Persons who meet criteria for mild cognitive impairment (MCI) exhibit measurable cognitive deficits but those deficits are not severe enough to interfere significantly with daily life. While the presence of MCI in PD increases the chance of developing dementia, various studies suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses. In this paper we comment on various biomarkers associated with cognitive decline in PD, specifically clinical, neuropathological, genetic and neuroimaging ones. We also discuss disrupted functional connectivity in PD-MCI and reveal preliminary result...Continue Reading

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Citations

Oct 30, 2016·Neuropsychologia·Florian LangeBruno Kopp
Mar 27, 2019·Geriatrics & Gerontology International·Luiz Felipe R VasconcellosMariana Spitz
Sep 25, 2020·Journal of the International Neuropsychological Society : JINS·Antònia Siquier, Pilar Andrés
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Feb 10, 2019·International Journal of Molecular Sciences·Dong-Hee ChoiJongmin Lee
Feb 2, 2021·Frontiers in Aging Neuroscience·Antònia Siquier, Pilar Andrés
May 1, 2021·Journal of Clinical Medicine·Eduardo Candel-ParraMilagros Molina-Alarcón
Jun 30, 2021·Journal of Neuroscience Research·Hannah D LoennekerHans-Christoph Nuerk

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