Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma

The Journal of Allergy and Clinical Immunology. in Practice
Joe K GeraldFernando D Martinez

Abstract

Inhaled corticosteroids are recommended as first-line therapy for children with mild persistent asthma; however, specific patient characteristics may modify the treatment response. Identify demographic, clinical, and atopic characteristics that may modify the inhaled corticosteroid treatment response among children enrolled in the Treating Children to Prevent Exacerbations of Asthma trial. Children aged 6 to 18 years with mild persistent asthma were randomized to 44 weeks of combined, daily, rescue, or placebo treatment. Daily treatment consisted of 40 μg of beclomethasone twice daily. Rescue treatment consisted of 40 μg of beclomethasone accompanying each symptom-driven albuterol actuation. Combined treatment consisted of both. Outcomes included time to first exacerbation and proportion of asthma control days. Fourteen baseline characteristics were selected for interaction testing on the basis of their clinical relevance. Two hundred eighty-eight children were randomized. Seventy-five percent were white, and 55% were male. As measured by time to first exacerbation, 4 characteristics identified children who received greater benefit from treatment: non-Hispanic ethnicity, positive aeroallergen skin test result, serum immunoglobu...Continue Reading

References

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Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Robert S ZeigerUNKNOWN Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
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Citations

May 9, 2016·The Journal of Allergy and Clinical Immunology·Alalia Berry, William W Busse
Sep 25, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Calvin J Small, Michael Gillespie
Nov 28, 2017·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Harold KimJason Lee
Dec 9, 2017·BMC Pulmonary Medicine·Yi-Fan WuYungling L Lee
Dec 28, 2017·Pediatric Allergy, Immunology, and Pulmonology·Hengameh Raissy, Kathryn Blake
Apr 17, 2020·Pediatric Pulmonology·Carlos E Rodriguez-MartinezJose A Castro-Rodriguez
Jun 27, 2017·Journal of Clinical and Translational Science·Kim D LuDan M Cooper
Sep 13, 2018·Clinical Reviews in Allergy & Immunology·Merin E KuruvillaGerald B Lee
Jan 12, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Ahmed EdrisLies Lahousse

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