Markers of fibrinolysis may predict development of lower extremity arterial disease in patients with diabetes: A longitudinal prospective cohort study with 10 years of follow-up

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Aslak RautioMaria K Svensson

Abstract

A previous cross-sectional study suggested that tissue plasminogen activator-activity might be an early marker of asymptomatic lower extremity arterial disease, but the long-term relationship is unknown. This study included 96 diabetic (48 type 1/48 type 2) and 62 non-diabetic subjects aged 30-70 years without previously known lower extremity arterial disease (age: 50.3 ± 9.3 years, gender: M/W 47.5/52.5% and body mass index: 26.6 ± 4.5 kg/m(2)). The relationships between asymptomatic lower extremity arterial disease and fibrinolytic markers (tissue plasminogen activator-activity, tissue plasminogen activator-mass, plasminogen activator inhibitor-1 activity) at baseline and after 10 years were assessed by logistic regression analysis adjusting for age, hypertension, statin treatment, HbA1c, triglycerides and low-density lipoprotein cholesterol as fixed covariates. The tissue plasminogen activator-activity at baseline and at the 10-year follow-up significantly predicted the presence of sign(s) of lower extremity arterial disease (odds ratio = 1.78, 95% confidence interval: 1.02-3.10, p = 0.043 and odds ratio = 1.78, 95% confidence interval: 1.12-2.23, p = 0.014, respectively). In addition, tissue plasminogen activator-mass at th...Continue Reading

References

Jan 14, 2000·JAMA : the Journal of the American Medical Association·J B MeigsP W Wilson
Sep 4, 2001·Vascular Medicine·S Mätzke, M Lepäntalo
Nov 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Jun 3, 2004·Circulation·Richard C PasternakUNKNOWN American Heart Association
Mar 16, 2005·Journal of Vascular Surgery·Francesco SofiDomenico Prisco
Aug 26, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Marie-Christine Alessi, Irène Juhan-Vague
Feb 19, 2008·Journal of Diabetes and Its Complications·Aziz NatherEileen Y Sim
Jan 8, 2010·Thrombosis Research·Jenny Hernestål-BomanLars Johansson
Feb 4, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·E B JudeN Tentolouris
Dec 20, 2012·Cardiovascular Diabetology·Jenny Hernestål-BomanLars Johansson
Jul 3, 2013·Current Opinion in Hematology·Ilya O Blokhin, Steven R Lentz
Apr 25, 2015·Circulation Research·Michael H Criqui, Victor Aboyans

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Citations

Aug 14, 2019·Upsala Journal of Medical Sciences·Desirée EdénAgneta Siegbahn
Oct 13, 2020·International Wound Journal·Yimeng Gao, Hongzhong Jin

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